A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein

The XJCl3 strain of Junin virus (JV) and the mouse-attenuated mutant Cl67 showed different GP 38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycopro...

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Detalles Bibliográficos
Autores principales: Scolaro, L.A., Mersich, S.E., Damonte, E.B.
Formato: JOUR
Materias:
virus envelope protein
virus glycoprotein
article
junin virus
nonhuman
virus attenuation
Animal
Arenaviridae
Arenaviruses, New World
Electrophoresis, Polyacrylamide Gel
Glycoproteins
Mice
Mutation
Peptide Mapping
Support, Non-U.S. Gov't
Viral Envelope Proteins
Virus Replication
Junin virus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03048608_v111_n3-4_p257_Scolaro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The XJCl3 strain of Junin virus (JV) and the mouse-attenuated mutant Cl67 showed different GP 38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycoprotein alteration and JV virulence in neonatal mice is proposed. © 1990 Springer-Verlag.

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