Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?

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Interactions among different species of parasites co-infecting the same host could be synergistic or antagonistic. These interactions may modify both the frequency of infected hosts and their infectiousness, and therefore impact on transmission dynamics. This study determined the infectiousness of T...

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Autores principales:	Enriquez, G.F., Garbossa, G., Macchiaverna, N.P., Argibay, H.D., Bua, J., Gürtler, R.E., Cardinal, M.V.
Formato:	JOUR
Materias:	Dogs Infectiousness Interspecies interactions Poly-parasitism Trypanosoma cruzi adult Ancylostoma caninum animal experiment Argentina Article Chagas disease controlled study cross-sectional study disease transmission host parasite interaction Neospora caninum nonhuman parasite load parasitism polymerase chain reaction polyparasitism rural area Toxoplasma gondii Triatoma infestans xenodiagnosis animal animal parasitosis complication dog dog disease isolation and purification mixed infection parasitology pathology veterinary Animals Chagas Disease Coinfection Dog Diseases Helminthiasis, Animal
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03044017_v223_n_p186_Enriquez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03044017_v223_n_p186_Enriquez2023-10-03T15:20:36Z Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism? Enriquez, G.F. Garbossa, G. Macchiaverna, N.P. Argibay, H.D. Bua, J. Gürtler, R.E. Cardinal, M.V. Dogs Infectiousness Interspecies interactions Poly-parasitism Trypanosoma cruzi adult Ancylostoma caninum animal experiment Argentina Article Chagas disease controlled study cross-sectional study disease transmission host parasite interaction Neospora caninum nonhuman parasite load parasitism polymerase chain reaction polyparasitism rural area Toxoplasma gondii Triatoma infestans Trypanosoma cruzi xenodiagnosis animal animal parasitosis Chagas disease complication dog dog disease isolation and purification mixed infection parasitology pathology veterinary Animals Chagas Disease Coinfection Dog Diseases Dogs Helminthiasis, Animal Trypanosoma cruzi Interactions among different species of parasites co-infecting the same host could be synergistic or antagonistic. These interactions may modify both the frequency of infected hosts and their infectiousness, and therefore impact on transmission dynamics. This study determined the infectiousness of Trypanosoma cruzi-seropositive dogs (using xenodiagnosis) and their parasite load (quantified by qPCR), and tested the association between both variables and the presence of concomitant endoparasites. A cross-sectional serosurvey conducted in eight rural villages from Pampa del Indio and neighboring municipalities (northeastern Argentina) detected 32 T. cruzi-seropositive dogs out of 217 individuals examined for infection. Both the infectiousness to the vector Triatoma infestans and parasite load of T. cruzi-seropositive dogs examined were heterogeneous. A statistically significant, nine-fold higher mean infectiousness was registered in T. cruzi-seropositive dogs co-infected with Ancylostoma caninum and a trematode than in T. cruzi-seropositive dogs without these infections. The median parasite load of T. cruzi was also significantly higher in dogs co-infected with these helminths. An opposite trend was observed in T. cruzi-seropositive dogs that were serologically positive to Toxoplasma gondii or Neospora caninum relative to dogs seronegative for these parasites. Using multiple logistic regression analysis with random effects, we found a positive and significant association between the infectiousness of T. cruzi-seropositive dogs and co-infections with A. caninum and a trematode. Our results suggest that co-infections may be a modifier of host infectiousness in dogs naturally infected with T. cruzi. © 2016 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03044017_v223_n_p186_Enriquez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dogs Infectiousness Interspecies interactions Poly-parasitism Trypanosoma cruzi adult Ancylostoma caninum animal experiment Argentina Article Chagas disease controlled study cross-sectional study disease transmission host parasite interaction Neospora caninum nonhuman parasite load parasitism polymerase chain reaction polyparasitism rural area Toxoplasma gondii Triatoma infestans Trypanosoma cruzi xenodiagnosis animal animal parasitosis Chagas disease complication dog dog disease isolation and purification mixed infection parasitology pathology veterinary Animals Chagas Disease Coinfection Dog Diseases Dogs Helminthiasis, Animal Trypanosoma cruzi
spellingShingle	Dogs Infectiousness Interspecies interactions Poly-parasitism Trypanosoma cruzi adult Ancylostoma caninum animal experiment Argentina Article Chagas disease controlled study cross-sectional study disease transmission host parasite interaction Neospora caninum nonhuman parasite load parasitism polymerase chain reaction polyparasitism rural area Toxoplasma gondii Triatoma infestans Trypanosoma cruzi xenodiagnosis animal animal parasitosis Chagas disease complication dog dog disease isolation and purification mixed infection parasitology pathology veterinary Animals Chagas Disease Coinfection Dog Diseases Dogs Helminthiasis, Animal Trypanosoma cruzi Enriquez, G.F. Garbossa, G. Macchiaverna, N.P. Argibay, H.D. Bua, J. Gürtler, R.E. Cardinal, M.V. Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
topic_facet	Dogs Infectiousness Interspecies interactions Poly-parasitism Trypanosoma cruzi adult Ancylostoma caninum animal experiment Argentina Article Chagas disease controlled study cross-sectional study disease transmission host parasite interaction Neospora caninum nonhuman parasite load parasitism polymerase chain reaction polyparasitism rural area Toxoplasma gondii Triatoma infestans Trypanosoma cruzi xenodiagnosis animal animal parasitosis Chagas disease complication dog dog disease isolation and purification mixed infection parasitology pathology veterinary Animals Chagas Disease Coinfection Dog Diseases Dogs Helminthiasis, Animal Trypanosoma cruzi
description	Interactions among different species of parasites co-infecting the same host could be synergistic or antagonistic. These interactions may modify both the frequency of infected hosts and their infectiousness, and therefore impact on transmission dynamics. This study determined the infectiousness of Trypanosoma cruzi-seropositive dogs (using xenodiagnosis) and their parasite load (quantified by qPCR), and tested the association between both variables and the presence of concomitant endoparasites. A cross-sectional serosurvey conducted in eight rural villages from Pampa del Indio and neighboring municipalities (northeastern Argentina) detected 32 T. cruzi-seropositive dogs out of 217 individuals examined for infection. Both the infectiousness to the vector Triatoma infestans and parasite load of T. cruzi-seropositive dogs examined were heterogeneous. A statistically significant, nine-fold higher mean infectiousness was registered in T. cruzi-seropositive dogs co-infected with Ancylostoma caninum and a trematode than in T. cruzi-seropositive dogs without these infections. The median parasite load of T. cruzi was also significantly higher in dogs co-infected with these helminths. An opposite trend was observed in T. cruzi-seropositive dogs that were serologically positive to Toxoplasma gondii or Neospora caninum relative to dogs seronegative for these parasites. Using multiple logistic regression analysis with random effects, we found a positive and significant association between the infectiousness of T. cruzi-seropositive dogs and co-infections with A. caninum and a trematode. Our results suggest that co-infections may be a modifier of host infectiousness in dogs naturally infected with T. cruzi. © 2016 Elsevier B.V.
format	JOUR
author	Enriquez, G.F. Garbossa, G. Macchiaverna, N.P. Argibay, H.D. Bua, J. Gürtler, R.E. Cardinal, M.V.
author_facet	Enriquez, G.F. Garbossa, G. Macchiaverna, N.P. Argibay, H.D. Bua, J. Gürtler, R.E. Cardinal, M.V.
author_sort	Enriquez, G.F.
title	Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
title_short	Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
title_full	Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
title_fullStr	Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
title_full_unstemmed	Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?
title_sort	is the infectiousness of dogs naturally infected with trypanosoma cruzi associated with poly-parasitism?
url	http://hdl.handle.net/20.500.12110/paper_03044017_v223_n_p186_Enriquez
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Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?

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