Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles

The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol do...

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Autores principales:	Prevedello, M.R., Ritta, M.N., Cardinali, D.P.
Formato:	JOUR
Materias:	5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03043940_v13_n1_p29_Prevedello2023-10-03T15:20:16Z Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles Prevedello, M.R. Ritta, M.N. Cardinali, D.P. 5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport. © 1979. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin
spellingShingle	5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin Prevedello, M.R. Ritta, M.N. Cardinali, D.P. Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
topic_facet	5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin
description	The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport. © 1979.
format	JOUR
author	Prevedello, M.R. Ritta, M.N. Cardinali, D.P.
author_facet	Prevedello, M.R. Ritta, M.N. Cardinali, D.P.
author_sort	Prevedello, M.R.
title	Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
title_short	Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
title_full	Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
title_fullStr	Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
title_full_unstemmed	Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
title_sort	fast axonal transport in rat sciatic nerve. inhibition by pineal indoles
url	http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello
work_keys_str_mv	AT prevedellomr fastaxonaltransportinratsciaticnerveinhibitionbypinealindoles AT rittamn fastaxonaltransportinratsciaticnerveinhibitionbypinealindoles AT cardinalidp fastaxonaltransportinratsciaticnerveinhibitionbypinealindoles
_version_	1807315137289256960

Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles

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