Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats

The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content...

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Autores principales:	Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R., San Martín de Viala, L.C.
Formato:	JOUR
Materias:	heme pathway hexachlorobenzene mammary tumor N-nitroso-N-methylurea porphyrins porphyris methylnitrosourea animal experiment article breast breast tumor controlled study female nonhuman porphyria priority journal rat 5-Aminolevulinate Synthetase Animal Female Hexachlorobenzene Mammary Neoplasms, Experimental Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03043835_v55_n1_p67_WainstokdeCalmanovici
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03043835_v55_n1_p67_WainstokdeCalmanovici2023-10-03T15:20:06Z Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats Wainstok de Calmanovici, R. Cochón, A.C. Aldonatti, C. Bergoc, R. San Martín de Viala, L.C. heme pathway hexachlorobenzene mammary tumor N-nitroso-N-methylurea porphyrins porphyris hexachlorobenzene methylnitrosourea animal experiment article breast breast tumor controlled study female nonhuman porphyria priority journal rat 5-Aminolevulinate Synthetase Animal Female Hexachlorobenzene Mammary Neoplasms, Experimental Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Animalia The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content in liver and tumor were measured. The results obtained indicate that the metabolic heme pathway operates in mammary tumors but tumor response to HCB treatment could not be detected. HCB administration produced an earlier and greater hepatic porphyria in tumor-bearing rats than in healthy rats suggesting that the presence of tumors exacerbates the action of HCB. © 1990. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cochón, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03043835_v55_n1_p67_WainstokdeCalmanovici
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	heme pathway hexachlorobenzene mammary tumor N-nitroso-N-methylurea porphyrins porphyris hexachlorobenzene methylnitrosourea animal experiment article breast breast tumor controlled study female nonhuman porphyria priority journal rat 5-Aminolevulinate Synthetase Animal Female Hexachlorobenzene Mammary Neoplasms, Experimental Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Animalia
spellingShingle	heme pathway hexachlorobenzene mammary tumor N-nitroso-N-methylurea porphyrins porphyris hexachlorobenzene methylnitrosourea animal experiment article breast breast tumor controlled study female nonhuman porphyria priority journal rat 5-Aminolevulinate Synthetase Animal Female Hexachlorobenzene Mammary Neoplasms, Experimental Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Animalia Wainstok de Calmanovici, R. Cochón, A.C. Aldonatti, C. Bergoc, R. San Martín de Viala, L.C. Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
topic_facet	heme pathway hexachlorobenzene mammary tumor N-nitroso-N-methylurea porphyrins porphyris hexachlorobenzene methylnitrosourea animal experiment article breast breast tumor controlled study female nonhuman porphyria priority journal rat 5-Aminolevulinate Synthetase Animal Female Hexachlorobenzene Mammary Neoplasms, Experimental Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Animalia
description	The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content in liver and tumor were measured. The results obtained indicate that the metabolic heme pathway operates in mammary tumors but tumor response to HCB treatment could not be detected. HCB administration produced an earlier and greater hepatic porphyria in tumor-bearing rats than in healthy rats suggesting that the presence of tumors exacerbates the action of HCB. © 1990.
format	JOUR
author	Wainstok de Calmanovici, R. Cochón, A.C. Aldonatti, C. Bergoc, R. San Martín de Viala, L.C.
author_facet	Wainstok de Calmanovici, R. Cochón, A.C. Aldonatti, C. Bergoc, R. San Martín de Viala, L.C.
author_sort	Wainstok de Calmanovici, R.
title	Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
title_short	Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
title_full	Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
title_fullStr	Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
title_full_unstemmed	Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
title_sort	synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
url	http://hdl.handle.net/20.500.12110/paper_03043835_v55_n1_p67_WainstokdeCalmanovici
work_keys_str_mv	AT wainstokdecalmanovicir synergisticeffectofmammarytumorsonhexachlorobenzeneinducedporphyriainrats AT cochonac synergisticeffectofmammarytumorsonhexachlorobenzeneinducedporphyriainrats AT aldonattic synergisticeffectofmammarytumorsonhexachlorobenzeneinducedporphyriainrats AT bergocr synergisticeffectofmammarytumorsonhexachlorobenzeneinducedporphyriainrats AT sanmartindevialalc synergisticeffectofmammarytumorsonhexachlorobenzeneinducedporphyriainrats
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Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats

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