DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate

The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experiment...

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Detalles Bibliográficos
Autores principales: Crespi, M.D., Radicella, J.P., Baldi, A., Charreau, E.H., Calvo, J.C.
Formato: JOUR
Materias:
DNA topoisomerase I
Leydig cell
Nuclear effect
Peptide hormone
cyclic amp
dna
dna topoisomerase
luteinizing hormone
peptide
animal cell
leydig cell
male genital system
nonhuman
nucleus
priority journal
rat
Animals
Carrier Proteins
Cyclic AMP
DNA Topoisomerases, Type I
Gonadotropins
Intracellular Signaling Peptides and Proteins
Leydig Cells
Luteinizing Hormone
Male
Rats
Rats, Inbred Strains
Testosterone
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v53_n3_p221_Crespi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action. © 1987.

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