Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes

Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box...

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Detalles Bibliográficos
Autores principales: Musikant, D., Sato, H., Capobianco, E., White, V., Jawerbaum, A., Higa, R.
Formato: JOUR
Materias:
Connexin43
Diabetes
FOXO1
Heart
Intrauterine programming
Matrix metalloproteinases
collagen
connexin 43
messenger RNA
streptozocin
transcription factor FKHR
adult
animal experiment
animal model
animal tissue
Article
cardiomyopathy
cardiovascular parameters
controlled study
Ctgf gene
enzyme activation
extracellular matrix
female
gene
gene targeting
heart
hyperglycemia
hypertriglyceridemia
insulinemia
male
maternal diabetes mellitus
Mmp 2 gene
nonhuman
pathogenesis
priority journal
progeny
protein function
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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