Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant |
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todo:paper_03037207_v479_n_p78_Musikant2023-10-03T15:19:59Z Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes Musikant, D. Sato, H. Capobianco, E. White, V. Jawerbaum, A. Higa, R. Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats. In the heart, an increase in active FOXO1 and mRNA levels of its target genes, Mmp-2 and Ctgf, genes related to an altered extracellular matrix remodeling, together with an increase in collagen deposition and a decrease in the connexin43 levels, were found in the offspring from diabetic rats. Altogether, these results suggest an important role of FOXO1 activation in the cardiac alterations induced by intrauterine programming in maternal diabetes. © 2018 JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat |
| spellingShingle |
Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat Musikant, D. Sato, H. Capobianco, E. White, V. Jawerbaum, A. Higa, R. Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| topic_facet |
Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat |
| description |
Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats. In the heart, an increase in active FOXO1 and mRNA levels of its target genes, Mmp-2 and Ctgf, genes related to an altered extracellular matrix remodeling, together with an increase in collagen deposition and a decrease in the connexin43 levels, were found in the offspring from diabetic rats. Altogether, these results suggest an important role of FOXO1 activation in the cardiac alterations induced by intrauterine programming in maternal diabetes. © 2018 |
| format |
JOUR |
| author |
Musikant, D. Sato, H. Capobianco, E. White, V. Jawerbaum, A. Higa, R. |
| author_facet |
Musikant, D. Sato, H. Capobianco, E. White, V. Jawerbaum, A. Higa, R. |
| author_sort |
Musikant, D. |
| title |
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| title_short |
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| title_full |
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| title_fullStr |
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| title_full_unstemmed |
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes |
| title_sort |
altered foxo1 activation in the programming of cardiovascular alterations by maternal diabetes |
| url |
http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant |
| work_keys_str_mv |
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1807317564285517824 |