Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome

Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased i...

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Autores principales: Di Pietro, M., Scotti, L., Irusta, G., Tesone, M., Parborell, F., Abramovich, D.
Formato: JOUR
Materias:
Angiogenesis
Ovary
Platelet derived growth factor
Polycystic ovary syndrome
Muellerian inhibiting factor
prasterone
recombinant platelet derived growth factor
recombinant platelet derived growth factor B
unclassified drug
vasculotropin
platelet derived growth factor B
vasculotropin A
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
corpus luteum
drug efficacy
drug mechanism
endothelium cell
female
hormone synthesis
nonhuman
ovary cyst
ovary development
ovary follicle development
ovary polycystic disease
ovulation
periendothelium cell
priority journal
rat
animal
drug effects
metabolism
Neovascularization, Pathologic
Ovarian Hyperstimulation Syndrome
ovary follicle
ovary follicle fluid
Polycystic Ovary Syndrome
Sprague Dawley rat
Animals
Anti-Mullerian Hormone
Female
Follicular Fluid
Ovarian Follicle
Ovulation
Proto-Oncogene Proteins c-sis
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_03037207_v433_n_p47_DiPietro2023-10-03T15:19:58Z Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome Di Pietro, M. Scotti, L. Irusta, G. Tesone, M. Parborell, F. Abramovich, D. Angiogenesis Ovary Platelet derived growth factor Polycystic ovary syndrome Muellerian inhibiting factor prasterone recombinant platelet derived growth factor recombinant platelet derived growth factor B unclassified drug vasculotropin Muellerian inhibiting factor platelet derived growth factor B vasculotropin A animal cell animal experiment animal model animal tissue Article controlled study corpus luteum drug efficacy drug mechanism endothelium cell female hormone synthesis nonhuman ovary cyst ovary development ovary follicle development ovary polycystic disease ovulation periendothelium cell priority journal rat animal drug effects metabolism Neovascularization, Pathologic Ovarian Hyperstimulation Syndrome ovary follicle ovary follicle fluid ovulation Polycystic Ovary Syndrome Sprague Dawley rat Animals Anti-Mullerian Hormone Female Follicular Fluid Neovascularization, Pathologic Ovarian Follicle Ovarian Hyperstimulation Syndrome Ovulation Polycystic Ovary Syndrome Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. © 2016 Elsevier Ireland Ltd. Fil:Di Pietro, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Irusta, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Parborell, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Abramovich, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Angiogenesis
Ovary
Platelet derived growth factor
Polycystic ovary syndrome
Muellerian inhibiting factor
prasterone
recombinant platelet derived growth factor
recombinant platelet derived growth factor B
unclassified drug
vasculotropin
Muellerian inhibiting factor
platelet derived growth factor B
vasculotropin A
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
corpus luteum
drug efficacy
drug mechanism
endothelium cell
female
hormone synthesis
nonhuman
ovary cyst
ovary development
ovary follicle development
ovary polycystic disease
ovulation
periendothelium cell
priority journal
rat
animal
drug effects
metabolism
Neovascularization, Pathologic
Ovarian Hyperstimulation Syndrome
ovary follicle
ovary follicle fluid
ovulation
Polycystic Ovary Syndrome
Sprague Dawley rat
Animals
Anti-Mullerian Hormone
Female
Follicular Fluid
Neovascularization, Pathologic
Ovarian Follicle
Ovarian Hyperstimulation Syndrome
Ovulation
Polycystic Ovary Syndrome
Proto-Oncogene Proteins c-sis
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A
spellingShingle Angiogenesis
Ovary
Platelet derived growth factor
Polycystic ovary syndrome
Muellerian inhibiting factor
prasterone
recombinant platelet derived growth factor
recombinant platelet derived growth factor B
unclassified drug
vasculotropin
Muellerian inhibiting factor
platelet derived growth factor B
vasculotropin A
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
corpus luteum
drug efficacy
drug mechanism
endothelium cell
female
hormone synthesis
nonhuman
ovary cyst
ovary development
ovary follicle development
ovary polycystic disease
ovulation
periendothelium cell
priority journal
rat
animal
drug effects
metabolism
Neovascularization, Pathologic
Ovarian Hyperstimulation Syndrome
ovary follicle
ovary follicle fluid
ovulation
Polycystic Ovary Syndrome
Sprague Dawley rat
Animals
Anti-Mullerian Hormone
Female
Follicular Fluid
Neovascularization, Pathologic
Ovarian Follicle
Ovarian Hyperstimulation Syndrome
Ovulation
Polycystic Ovary Syndrome
Proto-Oncogene Proteins c-sis
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A
Di Pietro, M.
Scotti, L.
Irusta, G.
Tesone, M.
Parborell, F.
Abramovich, D.
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
topic_facet Angiogenesis
Ovary
Platelet derived growth factor
Polycystic ovary syndrome
Muellerian inhibiting factor
prasterone
recombinant platelet derived growth factor
recombinant platelet derived growth factor B
unclassified drug
vasculotropin
Muellerian inhibiting factor
platelet derived growth factor B
vasculotropin A
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
corpus luteum
drug efficacy
drug mechanism
endothelium cell
female
hormone synthesis
nonhuman
ovary cyst
ovary development
ovary follicle development
ovary polycystic disease
ovulation
periendothelium cell
priority journal
rat
animal
drug effects
metabolism
Neovascularization, Pathologic
Ovarian Hyperstimulation Syndrome
ovary follicle
ovary follicle fluid
ovulation
Polycystic Ovary Syndrome
Sprague Dawley rat
Animals
Anti-Mullerian Hormone
Female
Follicular Fluid
Neovascularization, Pathologic
Ovarian Follicle
Ovarian Hyperstimulation Syndrome
Ovulation
Polycystic Ovary Syndrome
Proto-Oncogene Proteins c-sis
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A
description Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. © 2016 Elsevier Ireland Ltd.
format JOUR
author Di Pietro, M.
Scotti, L.
Irusta, G.
Tesone, M.
Parborell, F.
Abramovich, D.
author_facet Di Pietro, M.
Scotti, L.
Irusta, G.
Tesone, M.
Parborell, F.
Abramovich, D.
author_sort Di Pietro, M.
title Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
title_short Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
title_full Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
title_fullStr Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
title_full_unstemmed Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
title_sort local administration of platelet-derived growth factor b (pdgfb) improves follicular development and ovarian angiogenesis in a rat model of polycystic ovary syndrome
url http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro
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AT irustag localadministrationofplateletderivedgrowthfactorbpdgfbimprovesfolliculardevelopmentandovarianangiogenesisinaratmodelofpolycysticovarysyndrome
AT tesonem localadministrationofplateletderivedgrowthfactorbpdgfbimprovesfolliculardevelopmentandovarianangiogenesisinaratmodelofpolycysticovarysyndrome
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