Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells
NGF has anti-proliferative and anti-invasive effects in neuroendocrine tumors. In the present work we examined the effects of NGF and retinoic acid on cell proliferation and invasion in thyroid carcinoma cells. We found that NGF and retinoic acid do not affect cell proliferation on their own but in...
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todo:paper_03037207_v167_n1-2_p99_PaezPereda2023-10-03T15:19:46Z Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells Páez Pereda, M. Missale, C. Grübler, Y. Arzt, E. Schaaf, L. Stalla, G.K. Invasion Nerve growth factor Retinoic acid Thyroid papillary carcinoma collagen type 4 gelatinase A laminin nerve growth factor retinoic acid article cancer cell culture cancer inhibition cancer invasion cell adhesion controlled study drug mechanism drug potency drug potentiation enzyme regulation human human cell metastasis inhibition priority journal thyroid papillary carcinoma Antineoplastic Agents Carcinoma, Papillary Cell Adhesion Cell Division Cell Movement Gelatinase A Human Neoplasm Invasiveness Nerve Growth Factor Receptor, Nerve Growth Factor Support, Non-U.S. Gov't Thyroid Neoplasms Tretinoin Tumor Cells, Cultured NGF has anti-proliferative and anti-invasive effects in neuroendocrine tumors. In the present work we examined the effects of NGF and retinoic acid on cell proliferation and invasion in thyroid carcinoma cells. We found that NGF and retinoic acid do not affect cell proliferation on their own but in combination they produce a strong inhibition. We also found that retinoic acid regulates the matrix metalloproteinase 2 activity and invasion. In contrast, NGF inhibited invasion and reverted the effect of retinoic acid. This effect of NGF is likely mediated by an increase in adhesion to laminin and collagen IV and the inhibition of cell migration. NGF also induced the expression of the p75 NGF receptor. In conclusion, NGF and retinoic acid in combination inhibit proliferation and invasion of thyroid papillary carcinoma cells. These data open the possibility of a potential combined therapy for thyroid papillary carcinomas. (C) 2000 Elsevier Science Ireland Ltd. Fil:Páez Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v167_n1-2_p99_PaezPereda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Invasion Nerve growth factor Retinoic acid Thyroid papillary carcinoma collagen type 4 gelatinase A laminin nerve growth factor retinoic acid article cancer cell culture cancer inhibition cancer invasion cell adhesion controlled study drug mechanism drug potency drug potentiation enzyme regulation human human cell metastasis inhibition priority journal thyroid papillary carcinoma Antineoplastic Agents Carcinoma, Papillary Cell Adhesion Cell Division Cell Movement Gelatinase A Human Neoplasm Invasiveness Nerve Growth Factor Receptor, Nerve Growth Factor Support, Non-U.S. Gov't Thyroid Neoplasms Tretinoin Tumor Cells, Cultured |
| spellingShingle |
Invasion Nerve growth factor Retinoic acid Thyroid papillary carcinoma collagen type 4 gelatinase A laminin nerve growth factor retinoic acid article cancer cell culture cancer inhibition cancer invasion cell adhesion controlled study drug mechanism drug potency drug potentiation enzyme regulation human human cell metastasis inhibition priority journal thyroid papillary carcinoma Antineoplastic Agents Carcinoma, Papillary Cell Adhesion Cell Division Cell Movement Gelatinase A Human Neoplasm Invasiveness Nerve Growth Factor Receptor, Nerve Growth Factor Support, Non-U.S. Gov't Thyroid Neoplasms Tretinoin Tumor Cells, Cultured Páez Pereda, M. Missale, C. Grübler, Y. Arzt, E. Schaaf, L. Stalla, G.K. Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| topic_facet |
Invasion Nerve growth factor Retinoic acid Thyroid papillary carcinoma collagen type 4 gelatinase A laminin nerve growth factor retinoic acid article cancer cell culture cancer inhibition cancer invasion cell adhesion controlled study drug mechanism drug potency drug potentiation enzyme regulation human human cell metastasis inhibition priority journal thyroid papillary carcinoma Antineoplastic Agents Carcinoma, Papillary Cell Adhesion Cell Division Cell Movement Gelatinase A Human Neoplasm Invasiveness Nerve Growth Factor Receptor, Nerve Growth Factor Support, Non-U.S. Gov't Thyroid Neoplasms Tretinoin Tumor Cells, Cultured |
| description |
NGF has anti-proliferative and anti-invasive effects in neuroendocrine tumors. In the present work we examined the effects of NGF and retinoic acid on cell proliferation and invasion in thyroid carcinoma cells. We found that NGF and retinoic acid do not affect cell proliferation on their own but in combination they produce a strong inhibition. We also found that retinoic acid regulates the matrix metalloproteinase 2 activity and invasion. In contrast, NGF inhibited invasion and reverted the effect of retinoic acid. This effect of NGF is likely mediated by an increase in adhesion to laminin and collagen IV and the inhibition of cell migration. NGF also induced the expression of the p75 NGF receptor. In conclusion, NGF and retinoic acid in combination inhibit proliferation and invasion of thyroid papillary carcinoma cells. These data open the possibility of a potential combined therapy for thyroid papillary carcinomas. (C) 2000 Elsevier Science Ireland Ltd. |
| format |
JOUR |
| author |
Páez Pereda, M. Missale, C. Grübler, Y. Arzt, E. Schaaf, L. Stalla, G.K. |
| author_facet |
Páez Pereda, M. Missale, C. Grübler, Y. Arzt, E. Schaaf, L. Stalla, G.K. |
| author_sort |
Páez Pereda, M. |
| title |
Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| title_short |
Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| title_full |
Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| title_fullStr |
Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| title_full_unstemmed |
Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| title_sort |
nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells |
| url |
http://hdl.handle.net/20.500.12110/paper_03037207_v167_n1-2_p99_PaezPereda |
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1807316987698741248 |