Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis

The toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune response participating in the recognition of lipopolysaccharides. Changes in the innate immune response are involved in the pathogenesis of some metabolic disorders such as metabolic syndrome and type 2 diabetes mell...

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Autores principales:	S. Belforte, F., Coluccio Leskow, F., Poskus, E., Penas Steinhardt, A.
Formato:	JOUR
Materias:	D299G Diabetes Meta-analysis Metabolic syndrome Polymorphism TLR4 toll like receptor 4 article Caucasian cell interaction Crohn disease digestive system cancer disease association enteritis ethnicity gene frequency geographic distribution human metabolic disorder non insulin dependent diabetes mellitus protein polymorphism systematic review ulcerative colitis Diabetes Mellitus, Type 2 European Continental Ancestry Group Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Bowel Diseases Insulin Resistance Lipopolysaccharides Metabolic Syndrome X Phenotype Polymorphism, Single Nucleotide Risk Factors Toll-Like Receptor 4
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03014851_v40_n4_p3015_SBelforte
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03014851_v40_n4_p3015_SBelforte
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spelling	todo:paper_03014851_v40_n4_p3015_SBelforte2023-10-03T15:18:28Z Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis S. Belforte, F. Coluccio Leskow, F. Poskus, E. Penas Steinhardt, A. D299G Diabetes Meta-analysis Metabolic syndrome Polymorphism TLR4 toll like receptor 4 article Caucasian cell interaction Crohn disease digestive system cancer disease association enteritis ethnicity gene frequency geographic distribution human metabolic disorder non insulin dependent diabetes mellitus protein polymorphism systematic review ulcerative colitis Diabetes Mellitus, Type 2 European Continental Ancestry Group Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Bowel Diseases Insulin Resistance Lipopolysaccharides Metabolic Syndrome X Phenotype Polymorphism, Single Nucleotide Risk Factors Toll-Like Receptor 4 The toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune response participating in the recognition of lipopolysaccharides. Changes in the innate immune response are involved in the pathogenesis of some metabolic disorders such as metabolic syndrome and type 2 diabetes mellitus (Met-S and T2DM). It has been recently shown the role of gut microbiota in the perpetuation of both insulin resistance and low-grade chronic inflammation. Some studies have reported that TLR4 D299G polymorphism is associated with metabolic disorders, however results have been inconsistent. Two recent meta-analyses showed that D299G is associated with inflammatory bowel disease and gastrointestinal cancers risk, two pathological states in which the luminal microbial flora-host cells interaction may be implicated. We conducted a systemic review of the published data considering all eligible published studies (six studies with 1696 cases and 3388 controls for D299G) and a meta-analysis was performed to evaluate the association between TLR4 D299G polymorphism and the risk for metabolic disorders. Five studies were identified for T2DM: three corresponding to Caucasian populations and two to mixed populations. The remaining study analyzed Met-S in a Caucasian population. We observed a significant association between D299G polymorphism and metabolic disorders (T2DM and Met-S) risk (OR = 0.566, 95 % CI: 0.347-0.925, p = 0.023) particularly in Caucasians. No association was found in mixed population subgroup. Our meta-analysis identified that the AG/GG genotypes of D299G are associated with decreased metabolic disorders risk. © 2012 Springer Science+Business Media Dordrecht. Fil:Coluccio Leskow, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03014851_v40_n4_p3015_SBelforte
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	D299G Diabetes Meta-analysis Metabolic syndrome Polymorphism TLR4 toll like receptor 4 article Caucasian cell interaction Crohn disease digestive system cancer disease association enteritis ethnicity gene frequency geographic distribution human metabolic disorder non insulin dependent diabetes mellitus protein polymorphism systematic review ulcerative colitis Diabetes Mellitus, Type 2 European Continental Ancestry Group Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Bowel Diseases Insulin Resistance Lipopolysaccharides Metabolic Syndrome X Phenotype Polymorphism, Single Nucleotide Risk Factors Toll-Like Receptor 4
spellingShingle	D299G Diabetes Meta-analysis Metabolic syndrome Polymorphism TLR4 toll like receptor 4 article Caucasian cell interaction Crohn disease digestive system cancer disease association enteritis ethnicity gene frequency geographic distribution human metabolic disorder non insulin dependent diabetes mellitus protein polymorphism systematic review ulcerative colitis Diabetes Mellitus, Type 2 European Continental Ancestry Group Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Bowel Diseases Insulin Resistance Lipopolysaccharides Metabolic Syndrome X Phenotype Polymorphism, Single Nucleotide Risk Factors Toll-Like Receptor 4 S. Belforte, F. Coluccio Leskow, F. Poskus, E. Penas Steinhardt, A. Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
topic_facet	D299G Diabetes Meta-analysis Metabolic syndrome Polymorphism TLR4 toll like receptor 4 article Caucasian cell interaction Crohn disease digestive system cancer disease association enteritis ethnicity gene frequency geographic distribution human metabolic disorder non insulin dependent diabetes mellitus protein polymorphism systematic review ulcerative colitis Diabetes Mellitus, Type 2 European Continental Ancestry Group Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Bowel Diseases Insulin Resistance Lipopolysaccharides Metabolic Syndrome X Phenotype Polymorphism, Single Nucleotide Risk Factors Toll-Like Receptor 4
description	The toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune response participating in the recognition of lipopolysaccharides. Changes in the innate immune response are involved in the pathogenesis of some metabolic disorders such as metabolic syndrome and type 2 diabetes mellitus (Met-S and T2DM). It has been recently shown the role of gut microbiota in the perpetuation of both insulin resistance and low-grade chronic inflammation. Some studies have reported that TLR4 D299G polymorphism is associated with metabolic disorders, however results have been inconsistent. Two recent meta-analyses showed that D299G is associated with inflammatory bowel disease and gastrointestinal cancers risk, two pathological states in which the luminal microbial flora-host cells interaction may be implicated. We conducted a systemic review of the published data considering all eligible published studies (six studies with 1696 cases and 3388 controls for D299G) and a meta-analysis was performed to evaluate the association between TLR4 D299G polymorphism and the risk for metabolic disorders. Five studies were identified for T2DM: three corresponding to Caucasian populations and two to mixed populations. The remaining study analyzed Met-S in a Caucasian population. We observed a significant association between D299G polymorphism and metabolic disorders (T2DM and Met-S) risk (OR = 0.566, 95 % CI: 0.347-0.925, p = 0.023) particularly in Caucasians. No association was found in mixed population subgroup. Our meta-analysis identified that the AG/GG genotypes of D299G are associated with decreased metabolic disorders risk. © 2012 Springer Science+Business Media Dordrecht.
format	JOUR
author	S. Belforte, F. Coluccio Leskow, F. Poskus, E. Penas Steinhardt, A.
author_facet	S. Belforte, F. Coluccio Leskow, F. Poskus, E. Penas Steinhardt, A.
author_sort	S. Belforte, F.
title	Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
title_short	Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
title_full	Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
title_fullStr	Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
title_full_unstemmed	Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
title_sort	toll-like receptor 4 d299g polymorphism in metabolic disorders: a meta-analysis
url	http://hdl.handle.net/20.500.12110/paper_03014851_v40_n4_p3015_SBelforte
work_keys_str_mv	AT sbelfortef tolllikereceptor4d299gpolymorphisminmetabolicdisordersametaanalysis AT coluccioleskowf tolllikereceptor4d299gpolymorphisminmetabolicdisordersametaanalysis AT poskuse tolllikereceptor4d299gpolymorphisminmetabolicdisordersametaanalysis AT penassteinhardta tolllikereceptor4d299gpolymorphisminmetabolicdisordersametaanalysis
_version_	1807314414989213696

Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis

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