Implications of gamma band activity in the pedunculopontine nucleus
The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing stimuli simultaneously activate ascending projections of the PPN to the intralaminar thalamus to trigger cortic...
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todo:paper_03009564_v123_n7_p655_GarciaRill2023-10-03T15:18:02Z Implications of gamma band activity in the pedunculopontine nucleus Garcia-Rill, E. Luster, B. D’Onofrio, S. Mahaffey, S. Bisagno, V. Urbano, F.J. Arousal Gamma oscillations N-type P/Q-type Sleep/wake 4 aminobutyric acid receptor calcium channel calcium channel N type calcium channel P type calcium channel Q type cholinergic receptor stimulating agent glutamic acid lithium mitogen activated protein kinase 1 neuronal calcium sensor calcium channel bipolar disorder body posture brain depth stimulation cells by body anatomy clinical trial (topic) cluster analysis electroencephalogram gait gamma band activity gene overexpression hippocampus human insomnia mood disorder nonhuman Parkinson disease pedunculopontine tegmental nucleus physiological process priority journal REM sleep Review schizophrenia signal transduction sleep waking cycle substantia nigra pars compacta wakefulness animal brain disease gamma rhythm metabolism nerve tract pathology pedunculopontine tegmental nucleus physiology REM sleep wakefulness Animals Brain Diseases Calcium Channels Gamma Rhythm Humans Neural Pathways Pedunculopontine Tegmental Nucleus Sleep, REM Wakefulness The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing stimuli simultaneously activate ascending projections of the PPN to the intralaminar thalamus to trigger cortical high-frequency activity and arousal, as well as descending projections to reticulospinal systems to alter posture and locomotion. As such, the PPN has become a target for deep brain stimulation for the treatment of Parkinson’s disease, modulating gait, posture, and higher functions. This article describes the latest discoveries on PPN physiology and the role of the PPN in a number of disorders. It has now been determined that high-frequency activity during waking and REM sleep is controlled by two different intracellular pathways and two calcium channels in PPN cells. Moreover, there are three different PPN cell types that have one or both calcium channels and may be active during waking only, REM sleep only, or both. Based on the new discoveries, novel mechanisms are proposed for insomnia as a waking disorder. In addition, neuronal calcium sensor protein-1 (NCS-1), which is over expressed in schizophrenia and bipolar disorder, may be responsible for the dysregulation in gamma band activity in at least some patients with these diseases. Recent results suggest that NCS-1 modulates PPN gamma band activity and that lithium acts to reduce the effects of over expressed NCS-1, accounting for its effectiveness in bipolar disorder. © 2015, Springer-Verlag Wien. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03009564_v123_n7_p655_GarciaRill |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Arousal Gamma oscillations N-type P/Q-type Sleep/wake 4 aminobutyric acid receptor calcium channel calcium channel N type calcium channel P type calcium channel Q type cholinergic receptor stimulating agent glutamic acid lithium mitogen activated protein kinase 1 neuronal calcium sensor calcium channel bipolar disorder body posture brain depth stimulation cells by body anatomy clinical trial (topic) cluster analysis electroencephalogram gait gamma band activity gene overexpression hippocampus human insomnia mood disorder nonhuman Parkinson disease pedunculopontine tegmental nucleus physiological process priority journal REM sleep Review schizophrenia signal transduction sleep waking cycle substantia nigra pars compacta wakefulness animal brain disease gamma rhythm metabolism nerve tract pathology pedunculopontine tegmental nucleus physiology REM sleep wakefulness Animals Brain Diseases Calcium Channels Gamma Rhythm Humans Neural Pathways Pedunculopontine Tegmental Nucleus Sleep, REM Wakefulness |
| spellingShingle |
Arousal Gamma oscillations N-type P/Q-type Sleep/wake 4 aminobutyric acid receptor calcium channel calcium channel N type calcium channel P type calcium channel Q type cholinergic receptor stimulating agent glutamic acid lithium mitogen activated protein kinase 1 neuronal calcium sensor calcium channel bipolar disorder body posture brain depth stimulation cells by body anatomy clinical trial (topic) cluster analysis electroencephalogram gait gamma band activity gene overexpression hippocampus human insomnia mood disorder nonhuman Parkinson disease pedunculopontine tegmental nucleus physiological process priority journal REM sleep Review schizophrenia signal transduction sleep waking cycle substantia nigra pars compacta wakefulness animal brain disease gamma rhythm metabolism nerve tract pathology pedunculopontine tegmental nucleus physiology REM sleep wakefulness Animals Brain Diseases Calcium Channels Gamma Rhythm Humans Neural Pathways Pedunculopontine Tegmental Nucleus Sleep, REM Wakefulness Garcia-Rill, E. Luster, B. D’Onofrio, S. Mahaffey, S. Bisagno, V. Urbano, F.J. Implications of gamma band activity in the pedunculopontine nucleus |
| topic_facet |
Arousal Gamma oscillations N-type P/Q-type Sleep/wake 4 aminobutyric acid receptor calcium channel calcium channel N type calcium channel P type calcium channel Q type cholinergic receptor stimulating agent glutamic acid lithium mitogen activated protein kinase 1 neuronal calcium sensor calcium channel bipolar disorder body posture brain depth stimulation cells by body anatomy clinical trial (topic) cluster analysis electroencephalogram gait gamma band activity gene overexpression hippocampus human insomnia mood disorder nonhuman Parkinson disease pedunculopontine tegmental nucleus physiological process priority journal REM sleep Review schizophrenia signal transduction sleep waking cycle substantia nigra pars compacta wakefulness animal brain disease gamma rhythm metabolism nerve tract pathology pedunculopontine tegmental nucleus physiology REM sleep wakefulness Animals Brain Diseases Calcium Channels Gamma Rhythm Humans Neural Pathways Pedunculopontine Tegmental Nucleus Sleep, REM Wakefulness |
| description |
The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing stimuli simultaneously activate ascending projections of the PPN to the intralaminar thalamus to trigger cortical high-frequency activity and arousal, as well as descending projections to reticulospinal systems to alter posture and locomotion. As such, the PPN has become a target for deep brain stimulation for the treatment of Parkinson’s disease, modulating gait, posture, and higher functions. This article describes the latest discoveries on PPN physiology and the role of the PPN in a number of disorders. It has now been determined that high-frequency activity during waking and REM sleep is controlled by two different intracellular pathways and two calcium channels in PPN cells. Moreover, there are three different PPN cell types that have one or both calcium channels and may be active during waking only, REM sleep only, or both. Based on the new discoveries, novel mechanisms are proposed for insomnia as a waking disorder. In addition, neuronal calcium sensor protein-1 (NCS-1), which is over expressed in schizophrenia and bipolar disorder, may be responsible for the dysregulation in gamma band activity in at least some patients with these diseases. Recent results suggest that NCS-1 modulates PPN gamma band activity and that lithium acts to reduce the effects of over expressed NCS-1, accounting for its effectiveness in bipolar disorder. © 2015, Springer-Verlag Wien. |
| format |
JOUR |
| author |
Garcia-Rill, E. Luster, B. D’Onofrio, S. Mahaffey, S. Bisagno, V. Urbano, F.J. |
| author_facet |
Garcia-Rill, E. Luster, B. D’Onofrio, S. Mahaffey, S. Bisagno, V. Urbano, F.J. |
| author_sort |
Garcia-Rill, E. |
| title |
Implications of gamma band activity in the pedunculopontine nucleus |
| title_short |
Implications of gamma band activity in the pedunculopontine nucleus |
| title_full |
Implications of gamma band activity in the pedunculopontine nucleus |
| title_fullStr |
Implications of gamma band activity in the pedunculopontine nucleus |
| title_full_unstemmed |
Implications of gamma band activity in the pedunculopontine nucleus |
| title_sort |
implications of gamma band activity in the pedunculopontine nucleus |
| url |
http://hdl.handle.net/20.500.12110/paper_03009564_v123_n7_p655_GarciaRill |
| work_keys_str_mv |
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| _version_ |
1807318189788364800 |