The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures

The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevul...

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Detalles Bibliográficos
Autores principales: Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., Batlle, A.
Formato: JOUR
Materias:
Griseofulvin
Haem
N-methylporphyrins
Porphyrins
Tissue culture
griseofulvin
heme
porphyrin
animal cell
animal experiment
blood and hemopoietic system
congenital erythropoietic porphyria
drug mechanism
drug overdose
in vitro study
intoxication
liver
mouse
n methylporphyrin derivative
nonhuman
oral drug administration
skin
subcutaneous drug administration
tissue culture
Animal
Heme
Liver
Male
Mice
Skin
Support, Non-U.S. Gov't
Tissue Culture
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0300483X_v46_n1_p73_Vasquez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987.

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