The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures
The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevul...
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todo:paper_0300483X_v46_n1_p73_Vasquez2023-10-03T15:17:37Z The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures Vasquez, E. Afonso, S. Buzaleh, A.M. Navone, N. Polo, C. Schoua, E. Batlle, A. Griseofulvin Haem N-methylporphyrins Porphyrins Tissue culture griseofulvin heme porphyrin animal cell animal experiment blood and hemopoietic system congenital erythropoietic porphyria drug mechanism drug overdose in vitro study intoxication liver mouse n methylporphyrin derivative nonhuman oral drug administration skin subcutaneous drug administration tissue culture Animal Griseofulvin Heme Liver Male Mice Porphyrins Skin Support, Non-U.S. Gov't Tissue Culture The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987. Fil:Afonso, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0300483X_v46_n1_p73_Vasquez |
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Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Griseofulvin Haem N-methylporphyrins Porphyrins Tissue culture griseofulvin heme porphyrin animal cell animal experiment blood and hemopoietic system congenital erythropoietic porphyria drug mechanism drug overdose in vitro study intoxication liver mouse n methylporphyrin derivative nonhuman oral drug administration skin subcutaneous drug administration tissue culture Animal Griseofulvin Heme Liver Male Mice Porphyrins Skin Support, Non-U.S. Gov't Tissue Culture |
| spellingShingle |
Griseofulvin Haem N-methylporphyrins Porphyrins Tissue culture griseofulvin heme porphyrin animal cell animal experiment blood and hemopoietic system congenital erythropoietic porphyria drug mechanism drug overdose in vitro study intoxication liver mouse n methylporphyrin derivative nonhuman oral drug administration skin subcutaneous drug administration tissue culture Animal Griseofulvin Heme Liver Male Mice Porphyrins Skin Support, Non-U.S. Gov't Tissue Culture Vasquez, E. Afonso, S. Buzaleh, A.M. Navone, N. Polo, C. Schoua, E. Batlle, A. The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| topic_facet |
Griseofulvin Haem N-methylporphyrins Porphyrins Tissue culture griseofulvin heme porphyrin animal cell animal experiment blood and hemopoietic system congenital erythropoietic porphyria drug mechanism drug overdose in vitro study intoxication liver mouse n methylporphyrin derivative nonhuman oral drug administration skin subcutaneous drug administration tissue culture Animal Griseofulvin Heme Liver Male Mice Porphyrins Skin Support, Non-U.S. Gov't Tissue Culture |
| description |
The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987. |
| format |
JOUR |
| author |
Vasquez, E. Afonso, S. Buzaleh, A.M. Navone, N. Polo, C. Schoua, E. Batlle, A. |
| author_facet |
Vasquez, E. Afonso, S. Buzaleh, A.M. Navone, N. Polo, C. Schoua, E. Batlle, A. |
| author_sort |
Vasquez, E. |
| title |
The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| title_short |
The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| title_full |
The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| title_fullStr |
The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| title_full_unstemmed |
The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| title_sort |
effect of griseofulvin on the heme pathway. studies on tissue explant cultures |
| url |
http://hdl.handle.net/20.500.12110/paper_0300483X_v46_n1_p73_Vasquez |
| work_keys_str_mv |
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| _version_ |
1807318890096623616 |