Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity
Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins, a family of endogenous lectins widely expr...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_02719142_v31_n1_p10_Cerliani |
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todo:paper_02719142_v31_n1_p10_Cerliani2023-10-03T15:14:54Z Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity Cerliani, J.P. Stowell, S.R. Mascanfroni, I.D. Arthur, C.M. Cummings, R.D. Rabinovich, G.A. cytokines dendritic cells galectins glycoimmunology innate immunity macrophages mast cells Microbes neutrophils pattern recognition receptors galectin galectin 1 galectin 2 galectin 3 galectin 4 galectin 8 glycan Janus kinase 2 pattern recognition receptor resistin STAT1 protein STAT3 protein STAT5 protein adaptive immunity apoptosis binding affinity Candida albicans cell metabolism cell viability dendritic cell Escherichia coli host pathogen interaction immunoreactivity innate immunity macrophage mast cell neutrophil nonhuman plasticity pneumococcal infection priority journal protein analysis protein binding protein function protein phosphorylation protein protein interaction regulatory T lymphocyte review Saccharomyces cerevisiae sensitivity analysis signal transduction Animals Cytokines Galectins Host-Pathogen Interactions Humans Immunity, Innate Polysaccharides Receptors, Pattern Recognition Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins, a family of endogenous lectins widely expressed in infected and neoplastic tissues have emerged as part of the portfolio of soluble mediators and pattern recognition receptors responsible for eliciting and controlling innate immunity. These highly conserved glycan-binding proteins can control immune cell processes through binding to specific glycan structures on pathogens and tumors or by acting intracellularly via modulation of selective signaling pathways. Recent findings demonstrate that various galectin family members influence the fate and physiology of different innate immune cells including polymorphonuclear neutrophils, mast cells, macrophages, and dendritic cells. Moreover, several pathogens may actually utilize galectins as a mechanism of host invasion. In this review, we aim to highlight and integrate recent discoveries that have led to our current understanding of the role of galectins in host-pathogen interactions and innate immunity. Challenges for the future will embrace the rational manipulation of galectin-glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer. © 2010 Springer Science+Business Media, LLC. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02719142_v31_n1_p10_Cerliani |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cytokines dendritic cells galectins glycoimmunology innate immunity macrophages mast cells Microbes neutrophils pattern recognition receptors galectin galectin 1 galectin 2 galectin 3 galectin 4 galectin 8 glycan Janus kinase 2 pattern recognition receptor resistin STAT1 protein STAT3 protein STAT5 protein adaptive immunity apoptosis binding affinity Candida albicans cell metabolism cell viability dendritic cell Escherichia coli host pathogen interaction immunoreactivity innate immunity macrophage mast cell neutrophil nonhuman plasticity pneumococcal infection priority journal protein analysis protein binding protein function protein phosphorylation protein protein interaction regulatory T lymphocyte review Saccharomyces cerevisiae sensitivity analysis signal transduction Animals Cytokines Galectins Host-Pathogen Interactions Humans Immunity, Innate Polysaccharides Receptors, Pattern Recognition |
| spellingShingle |
cytokines dendritic cells galectins glycoimmunology innate immunity macrophages mast cells Microbes neutrophils pattern recognition receptors galectin galectin 1 galectin 2 galectin 3 galectin 4 galectin 8 glycan Janus kinase 2 pattern recognition receptor resistin STAT1 protein STAT3 protein STAT5 protein adaptive immunity apoptosis binding affinity Candida albicans cell metabolism cell viability dendritic cell Escherichia coli host pathogen interaction immunoreactivity innate immunity macrophage mast cell neutrophil nonhuman plasticity pneumococcal infection priority journal protein analysis protein binding protein function protein phosphorylation protein protein interaction regulatory T lymphocyte review Saccharomyces cerevisiae sensitivity analysis signal transduction Animals Cytokines Galectins Host-Pathogen Interactions Humans Immunity, Innate Polysaccharides Receptors, Pattern Recognition Cerliani, J.P. Stowell, S.R. Mascanfroni, I.D. Arthur, C.M. Cummings, R.D. Rabinovich, G.A. Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| topic_facet |
cytokines dendritic cells galectins glycoimmunology innate immunity macrophages mast cells Microbes neutrophils pattern recognition receptors galectin galectin 1 galectin 2 galectin 3 galectin 4 galectin 8 glycan Janus kinase 2 pattern recognition receptor resistin STAT1 protein STAT3 protein STAT5 protein adaptive immunity apoptosis binding affinity Candida albicans cell metabolism cell viability dendritic cell Escherichia coli host pathogen interaction immunoreactivity innate immunity macrophage mast cell neutrophil nonhuman plasticity pneumococcal infection priority journal protein analysis protein binding protein function protein phosphorylation protein protein interaction regulatory T lymphocyte review Saccharomyces cerevisiae sensitivity analysis signal transduction Animals Cytokines Galectins Host-Pathogen Interactions Humans Immunity, Innate Polysaccharides Receptors, Pattern Recognition |
| description |
Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins, a family of endogenous lectins widely expressed in infected and neoplastic tissues have emerged as part of the portfolio of soluble mediators and pattern recognition receptors responsible for eliciting and controlling innate immunity. These highly conserved glycan-binding proteins can control immune cell processes through binding to specific glycan structures on pathogens and tumors or by acting intracellularly via modulation of selective signaling pathways. Recent findings demonstrate that various galectin family members influence the fate and physiology of different innate immune cells including polymorphonuclear neutrophils, mast cells, macrophages, and dendritic cells. Moreover, several pathogens may actually utilize galectins as a mechanism of host invasion. In this review, we aim to highlight and integrate recent discoveries that have led to our current understanding of the role of galectins in host-pathogen interactions and innate immunity. Challenges for the future will embrace the rational manipulation of galectin-glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer. © 2010 Springer Science+Business Media, LLC. |
| format |
JOUR |
| author |
Cerliani, J.P. Stowell, S.R. Mascanfroni, I.D. Arthur, C.M. Cummings, R.D. Rabinovich, G.A. |
| author_facet |
Cerliani, J.P. Stowell, S.R. Mascanfroni, I.D. Arthur, C.M. Cummings, R.D. Rabinovich, G.A. |
| author_sort |
Cerliani, J.P. |
| title |
Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| title_short |
Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| title_full |
Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| title_fullStr |
Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| title_full_unstemmed |
Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity |
| title_sort |
expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity |
| url |
http://hdl.handle.net/20.500.12110/paper_02719142_v31_n1_p10_Cerliani |
| work_keys_str_mv |
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1807317773530955776 |