Alternative splicing switches: Important players in cell differentiation
Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiatio...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_02659247_v39_n6_p_Fiszbein |
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todo:paper_02659247_v39_n6_p_Fiszbein2023-10-03T15:13:23Z Alternative splicing switches: Important players in cell differentiation Fiszbein, A. Kornblihtt, A.R. alternative splicing cell differentiation chromatin structure neuronal differentiation RNA binding proteins spliceosome splicing factors RNA adipogenesis alternative RNA splicing cell differentiation chromatin structure embryonic stem cell gene expression human immunocompetent cell immunostimulation muscle development nerve cell differentiation nuclear reprogramming pluripotent stem cell regulatory mechanism Review animal cell differentiation genetics Alternative Splicing Animals Cell Differentiation Humans Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiation has been characterized for a variety of models, their causes and mechanisms remain largely unknown. Here, we integrate foundational and recent studies indicating the AS switches that govern the processes of cell fate determination. We include some distinct AS events in pluripotent cells and somatic reprogramming and discuss new progresses on alternative isoform expression in adipogenesis, myogenic differentiation and stimulation of immune cells. Finally, we cover novel insights on AS mechanisms during neuronal differentiation, paying special attention to the role of chromatin structure. © 2017 WILEY Periodicals, Inc. Fil:Fiszbein, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02659247_v39_n6_p_Fiszbein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alternative splicing cell differentiation chromatin structure neuronal differentiation RNA binding proteins spliceosome splicing factors RNA adipogenesis alternative RNA splicing cell differentiation chromatin structure embryonic stem cell gene expression human immunocompetent cell immunostimulation muscle development nerve cell differentiation nuclear reprogramming pluripotent stem cell regulatory mechanism Review animal cell differentiation genetics Alternative Splicing Animals Cell Differentiation Humans |
| spellingShingle |
alternative splicing cell differentiation chromatin structure neuronal differentiation RNA binding proteins spliceosome splicing factors RNA adipogenesis alternative RNA splicing cell differentiation chromatin structure embryonic stem cell gene expression human immunocompetent cell immunostimulation muscle development nerve cell differentiation nuclear reprogramming pluripotent stem cell regulatory mechanism Review animal cell differentiation genetics Alternative Splicing Animals Cell Differentiation Humans Fiszbein, A. Kornblihtt, A.R. Alternative splicing switches: Important players in cell differentiation |
| topic_facet |
alternative splicing cell differentiation chromatin structure neuronal differentiation RNA binding proteins spliceosome splicing factors RNA adipogenesis alternative RNA splicing cell differentiation chromatin structure embryonic stem cell gene expression human immunocompetent cell immunostimulation muscle development nerve cell differentiation nuclear reprogramming pluripotent stem cell regulatory mechanism Review animal cell differentiation genetics Alternative Splicing Animals Cell Differentiation Humans |
| description |
Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiation has been characterized for a variety of models, their causes and mechanisms remain largely unknown. Here, we integrate foundational and recent studies indicating the AS switches that govern the processes of cell fate determination. We include some distinct AS events in pluripotent cells and somatic reprogramming and discuss new progresses on alternative isoform expression in adipogenesis, myogenic differentiation and stimulation of immune cells. Finally, we cover novel insights on AS mechanisms during neuronal differentiation, paying special attention to the role of chromatin structure. © 2017 WILEY Periodicals, Inc. |
| format |
JOUR |
| author |
Fiszbein, A. Kornblihtt, A.R. |
| author_facet |
Fiszbein, A. Kornblihtt, A.R. |
| author_sort |
Fiszbein, A. |
| title |
Alternative splicing switches: Important players in cell differentiation |
| title_short |
Alternative splicing switches: Important players in cell differentiation |
| title_full |
Alternative splicing switches: Important players in cell differentiation |
| title_fullStr |
Alternative splicing switches: Important players in cell differentiation |
| title_full_unstemmed |
Alternative splicing switches: Important players in cell differentiation |
| title_sort |
alternative splicing switches: important players in cell differentiation |
| url |
http://hdl.handle.net/20.500.12110/paper_02659247_v39_n6_p_Fiszbein |
| work_keys_str_mv |
AT fiszbeina alternativesplicingswitchesimportantplayersincelldifferentiation AT kornblihttar alternativesplicingswitchesimportantplayersincelldifferentiation |
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1807323055986311168 |