Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease

We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesio...

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Detalles Bibliográficos
Autores principales: Wainszelbaum, M., Isola, E., Wilkowsky, S., Cannata, J.J.B., Florin-Christensen, J., Florin-Christensen, M.
Formato: JOUR
Materias:
Epimastigotes
Phosphatidylcholine
Phospholipids
Trypanosomiasis
Catalysis
Cells
Tissue
Pathogenesis
Enzymes
phosphatidylcholine
phospholipase A1
phospholipid
phospholipase A
animal cell
article
catalysis
cell death
Chagas disease
deacylation
enzyme activity
enzyme purification
epimastigote
life cycle
lysosome
nonhuman
pathogenesis
priority journal
Trypanosoma cruzi
trypanosomiasis
animal
enzymology
human
isolation and purification
metabolism
parasitology
pathogenicity
physiology
Animalia
Protozoa
Trypanosoma
Animals
Chagas Disease
Humans
Lysosomes
Phospholipases A
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02646021_v355_n3_p765_Wainszelbaum
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections.

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