Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease
We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesio...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_02646021_v355_n3_p765_Wainszelbaum |
| Aporte de: |
| id |
todo:paper_02646021_v355_n3_p765_Wainszelbaum |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_02646021_v355_n3_p765_Wainszelbaum2023-10-03T15:13:00Z Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease Wainszelbaum, M. Isola, E. Wilkowsky, S. Cannata, J.J.B. Florin-Christensen, J. Florin-Christensen, M. Epimastigotes Phosphatidylcholine Phospholipids Trypanosomiasis Catalysis Cells Phospholipids Tissue Pathogenesis Enzymes phosphatidylcholine phospholipase A1 phospholipid phospholipase A phospholipid animal cell article catalysis cell death Chagas disease deacylation enzyme activity enzyme purification epimastigote life cycle lysosome nonhuman pathogenesis priority journal Trypanosoma cruzi trypanosomiasis animal Chagas disease enzymology human isolation and purification lysosome metabolism parasitology pathogenicity physiology Animalia Protozoa Trypanosoma Trypanosoma cruzi Animals Catalysis Chagas Disease Humans Lysosomes Phospholipases A Phospholipids Trypanosoma cruzi We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02646021_v355_n3_p765_Wainszelbaum |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Epimastigotes Phosphatidylcholine Phospholipids Trypanosomiasis Catalysis Cells Phospholipids Tissue Pathogenesis Enzymes phosphatidylcholine phospholipase A1 phospholipid phospholipase A phospholipid animal cell article catalysis cell death Chagas disease deacylation enzyme activity enzyme purification epimastigote life cycle lysosome nonhuman pathogenesis priority journal Trypanosoma cruzi trypanosomiasis animal Chagas disease enzymology human isolation and purification lysosome metabolism parasitology pathogenicity physiology Animalia Protozoa Trypanosoma Trypanosoma cruzi Animals Catalysis Chagas Disease Humans Lysosomes Phospholipases A Phospholipids Trypanosoma cruzi |
| spellingShingle |
Epimastigotes Phosphatidylcholine Phospholipids Trypanosomiasis Catalysis Cells Phospholipids Tissue Pathogenesis Enzymes phosphatidylcholine phospholipase A1 phospholipid phospholipase A phospholipid animal cell article catalysis cell death Chagas disease deacylation enzyme activity enzyme purification epimastigote life cycle lysosome nonhuman pathogenesis priority journal Trypanosoma cruzi trypanosomiasis animal Chagas disease enzymology human isolation and purification lysosome metabolism parasitology pathogenicity physiology Animalia Protozoa Trypanosoma Trypanosoma cruzi Animals Catalysis Chagas Disease Humans Lysosomes Phospholipases A Phospholipids Trypanosoma cruzi Wainszelbaum, M. Isola, E. Wilkowsky, S. Cannata, J.J.B. Florin-Christensen, J. Florin-Christensen, M. Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| topic_facet |
Epimastigotes Phosphatidylcholine Phospholipids Trypanosomiasis Catalysis Cells Phospholipids Tissue Pathogenesis Enzymes phosphatidylcholine phospholipase A1 phospholipid phospholipase A phospholipid animal cell article catalysis cell death Chagas disease deacylation enzyme activity enzyme purification epimastigote life cycle lysosome nonhuman pathogenesis priority journal Trypanosoma cruzi trypanosomiasis animal Chagas disease enzymology human isolation and purification lysosome metabolism parasitology pathogenicity physiology Animalia Protozoa Trypanosoma Trypanosoma cruzi Animals Catalysis Chagas Disease Humans Lysosomes Phospholipases A Phospholipids Trypanosoma cruzi |
| description |
We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections. |
| format |
JOUR |
| author |
Wainszelbaum, M. Isola, E. Wilkowsky, S. Cannata, J.J.B. Florin-Christensen, J. Florin-Christensen, M. |
| author_facet |
Wainszelbaum, M. Isola, E. Wilkowsky, S. Cannata, J.J.B. Florin-Christensen, J. Florin-Christensen, M. |
| author_sort |
Wainszelbaum, M. |
| title |
Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| title_short |
Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| title_full |
Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| title_fullStr |
Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| title_full_unstemmed |
Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease |
| title_sort |
lysosomal phospholipase a1 in trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of chagas' disease |
| url |
http://hdl.handle.net/20.500.12110/paper_02646021_v355_n3_p765_Wainszelbaum |
| work_keys_str_mv |
AT wainszelbaumm lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease AT isolae lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease AT wilkowskys lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease AT cannatajjb lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease AT florinchristensenj lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease AT florinchristensenm lysosomalphospholipasea1intrypanosomacruzianenzymewithapossibleroleinthepathogenesisofchagasdisease |
| _version_ |
1807316346902413312 |