CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice

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De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccin...

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Autores principales: Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R.
Formato: JOUR
Materias:
CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
CD207(+) cells
Animals
Antigens, Surface
Cancer Vaccines
Cell Movement
Dendritic Cells
Lectins, C-Type
Lymph Nodes
Lymphoid Tissue
Mannose-Binding Lectins
Mice
Mice, Inbred C57BL
T-Lymphocytes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0264410X_v32_n11_p1229_Ruiz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0264410X_v32_n11_p1229_Ruiz
record_format dspace
spelling todo:paper_0264410X_v32_n11_p1229_Ruiz2023-10-03T15:12:50Z CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice Ruiz, M.S. Mac Keon, S. Campisano, S. Bravo, A.I. Gazzaniga, S. Wainstok, R. CD207+ cells Dendritic cells Ectopic lymphoid tissue Melanoma Vaccine CD207(+) cells Dendritic cells Ectopic lymphoid tissue Melanoma Vaccine Animals Antigens, Surface Cancer Vaccines Cell Movement Dendritic Cells Lectins, C-Type Lymph Nodes Lymphoid Tissue Mannose-Binding Lectins Melanoma Mice Mice, Inbred C57BL T-Lymphocytes De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. Fil:Gazzaniga, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0264410X_v32_n11_p1229_Ruiz
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
CD207(+) cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
Animals
Antigens, Surface
Cancer Vaccines
Cell Movement
Dendritic Cells
Lectins, C-Type
Lymph Nodes
Lymphoid Tissue
Mannose-Binding Lectins
Melanoma
Mice
Mice, Inbred C57BL
T-Lymphocytes
spellingShingle CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
CD207(+) cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
Animals
Antigens, Surface
Cancer Vaccines
Cell Movement
Dendritic Cells
Lectins, C-Type
Lymph Nodes
Lymphoid Tissue
Mannose-Binding Lectins
Melanoma
Mice
Mice, Inbred C57BL
T-Lymphocytes
Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
topic_facet CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
CD207(+) cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
Animals
Antigens, Surface
Cancer Vaccines
Cell Movement
Dendritic Cells
Lectins, C-Type
Lymph Nodes
Lymphoid Tissue
Mannose-Binding Lectins
Melanoma
Mice
Mice, Inbred C57BL
T-Lymphocytes
description De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd.
format JOUR
author Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
author_facet Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
author_sort Ruiz, M.S.
title CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_short CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_full CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_fullStr CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_full_unstemmed CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_sort cd207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of dc-apo/nec vaccine in mice
url http://hdl.handle.net/20.500.12110/paper_0264410X_v32_n11_p1229_Ruiz
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