Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate i...

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Autores principales:	Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., Zorzopulos, J., Frank, R.
Formato:	JOUR
Materias:	GM1-binding peptides Mucosal adjuvants Phage display bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide ganglioside GM1 immunological adjuvant peptide peptide library serine unclassified drug amino acid composition animal cell animal experiment antibody response article binding assay controlled study immunostimulation inoculation mouse nonhuman phage display priority journal protein motif Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Bacterial Antibodies, Viral Antigens, Bacterial Antigens, Viral Bronchoalveolar Lavage Fluid Cell Wall Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside Hemagglutinin Glycoproteins, Influenza Virus Immunoglobulin A Immunoglobulin G Influenza Vaccines Mice Mice, Inbred BALB C Neuraminidase Peptide Library Peptides Protein Binding Streptococcus pneumoniae
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0264410X_v24_n11_p1889_Montaner
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_0264410X_v24_n11_p1889_Montaner2023-10-03T15:12:49Z Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route Montaner, A.D. De Nichilo, A. Elias, F. Rodríguez, J.M. Fló, J.M. López, R.A. Zorzopulos, J. Frank, R. GM1-binding peptides Mucosal adjuvants Phage display bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide ganglioside GM1 immunological adjuvant peptide peptide library serine unclassified drug amino acid composition animal cell animal experiment antibody response article binding assay controlled study immunostimulation inoculation mouse nonhuman phage display priority journal protein motif Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Bacterial Antibodies, Viral Antigens, Bacterial Antigens, Viral Bronchoalveolar Lavage Fluid Cell Wall Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside Hemagglutinin Glycoproteins, Influenza Virus Immunoglobulin A Immunoglobulin G Influenza Vaccines Mice Mice, Inbred BALB C Neuraminidase Peptide Library Peptides Protein Binding Streptococcus pneumoniae Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate its immunostimulatory properties when chemically coupled to antigens. Mice intra-nasally (i.n.) vaccinated with some of these complexes developed a better local and systemic antibody response than mice i.n. vaccinated with the respective uncoupled antigens. The efficiency of the complex GM 1-binding peptide-antigen strongly depends on the composition and structure of both of the components of the complex. © 2005 Elsevier Ltd. All rights reserved. Fil:Elias, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0264410X_v24_n11_p1889_Montaner
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	GM1-binding peptides Mucosal adjuvants Phage display bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide ganglioside GM1 immunological adjuvant peptide peptide library serine unclassified drug amino acid composition animal cell animal experiment antibody response article binding assay controlled study immunostimulation inoculation mouse nonhuman phage display priority journal protein motif Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Bacterial Antibodies, Viral Antigens, Bacterial Antigens, Viral Bronchoalveolar Lavage Fluid Cell Wall Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside Hemagglutinin Glycoproteins, Influenza Virus Immunoglobulin A Immunoglobulin G Influenza Vaccines Mice Mice, Inbred BALB C Neuraminidase Peptide Library Peptides Protein Binding Streptococcus pneumoniae
spellingShingle	GM1-binding peptides Mucosal adjuvants Phage display bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide ganglioside GM1 immunological adjuvant peptide peptide library serine unclassified drug amino acid composition animal cell animal experiment antibody response article binding assay controlled study immunostimulation inoculation mouse nonhuman phage display priority journal protein motif Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Bacterial Antibodies, Viral Antigens, Bacterial Antigens, Viral Bronchoalveolar Lavage Fluid Cell Wall Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside Hemagglutinin Glycoproteins, Influenza Virus Immunoglobulin A Immunoglobulin G Influenza Vaccines Mice Mice, Inbred BALB C Neuraminidase Peptide Library Peptides Protein Binding Streptococcus pneumoniae Montaner, A.D. De Nichilo, A. Elias, F. Rodríguez, J.M. Fló, J.M. López, R.A. Zorzopulos, J. Frank, R. Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
topic_facet	GM1-binding peptides Mucosal adjuvants Phage display bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide ganglioside GM1 immunological adjuvant peptide peptide library serine unclassified drug amino acid composition animal cell animal experiment antibody response article binding assay controlled study immunostimulation inoculation mouse nonhuman phage display priority journal protein motif Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Bacterial Antibodies, Viral Antigens, Bacterial Antigens, Viral Bronchoalveolar Lavage Fluid Cell Wall Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside Hemagglutinin Glycoproteins, Influenza Virus Immunoglobulin A Immunoglobulin G Influenza Vaccines Mice Mice, Inbred BALB C Neuraminidase Peptide Library Peptides Protein Binding Streptococcus pneumoniae
description	Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate its immunostimulatory properties when chemically coupled to antigens. Mice intra-nasally (i.n.) vaccinated with some of these complexes developed a better local and systemic antibody response than mice i.n. vaccinated with the respective uncoupled antigens. The efficiency of the complex GM 1-binding peptide-antigen strongly depends on the composition and structure of both of the components of the complex. © 2005 Elsevier Ltd. All rights reserved.
format	JOUR
author	Montaner, A.D. De Nichilo, A. Elias, F. Rodríguez, J.M. Fló, J.M. López, R.A. Zorzopulos, J. Frank, R.
author_facet	Montaner, A.D. De Nichilo, A. Elias, F. Rodríguez, J.M. Fló, J.M. López, R.A. Zorzopulos, J. Frank, R.
author_sort	Montaner, A.D.
title	Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
title_short	Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
title_full	Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
title_fullStr	Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
title_full_unstemmed	Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
title_sort	ganglioside gm1-binding peptides as adjuvants of antigens inoculated by the intranasal route
url	http://hdl.handle.net/20.500.12110/paper_0264410X_v24_n11_p1889_Montaner
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Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

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