Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients

The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspiri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gimeno, M.F., Shattner, M.A., Borda, E., Gimeno, A.L., Lazzari, M.A.
Formato: JOUR
Materias:
5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
adenosine diphosphate
alcohol
arachidonic acid
collagen
dimethyl sulfoxide
nordihydroguaiaretic acid
adhesion
blood and hemopoietic system
cardiovascular system
controlled study
drug mechanism
drug sensitivity
human
human cell
patient
therapy
thrombocyte aggregation
thrombosis
5,8,11,14-Eicosatetraynoic Acid
Adenosine Diphosphate
Arachidonic Acid
Arachidonic Acids
Aspirin
Catechols
Collagen
Humans
Lipoxygenase Inhibitors
Nordihydroguaiaretic Acid
Platelet Adhesiveness
Platelet Aggregation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_02621746_v11_n1_p109_Gimeno
record_format dspace
spelling todo:paper_02621746_v11_n1_p109_Gimeno2023-10-03T15:12:34Z Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients Gimeno, M.F. Shattner, M.A. Borda, E. Gimeno, A.L. Lazzari, M.A. 5,8,11,14 icosatetraynoic acid acetylsalicylic acid adenosine diphosphate alcohol arachidonic acid collagen dimethyl sulfoxide nordihydroguaiaretic acid adhesion blood and hemopoietic system cardiovascular system controlled study drug mechanism drug sensitivity human human cell patient therapy thrombocyte aggregation thrombosis 5,8,11,14-Eicosatetraynoic Acid Adenosine Diphosphate Arachidonic Acid Arachidonic Acids Aspirin Catechols Collagen Humans Lipoxygenase Inhibitors Nordihydroguaiaretic Acid Platelet Adhesiveness Platelet Aggregation The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
adenosine diphosphate
alcohol
arachidonic acid
collagen
dimethyl sulfoxide
nordihydroguaiaretic acid
adhesion
blood and hemopoietic system
cardiovascular system
controlled study
drug mechanism
drug sensitivity
human
human cell
patient
therapy
thrombocyte aggregation
thrombosis
5,8,11,14-Eicosatetraynoic Acid
Adenosine Diphosphate
Arachidonic Acid
Arachidonic Acids
Aspirin
Catechols
Collagen
Humans
Lipoxygenase Inhibitors
Nordihydroguaiaretic Acid
Platelet Adhesiveness
Platelet Aggregation
spellingShingle 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
adenosine diphosphate
alcohol
arachidonic acid
collagen
dimethyl sulfoxide
nordihydroguaiaretic acid
adhesion
blood and hemopoietic system
cardiovascular system
controlled study
drug mechanism
drug sensitivity
human
human cell
patient
therapy
thrombocyte aggregation
thrombosis
5,8,11,14-Eicosatetraynoic Acid
Adenosine Diphosphate
Arachidonic Acid
Arachidonic Acids
Aspirin
Catechols
Collagen
Humans
Lipoxygenase Inhibitors
Nordihydroguaiaretic Acid
Platelet Adhesiveness
Platelet Aggregation
Gimeno, M.F.
Shattner, M.A.
Borda, E.
Gimeno, A.L.
Lazzari, M.A.
Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
topic_facet 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
adenosine diphosphate
alcohol
arachidonic acid
collagen
dimethyl sulfoxide
nordihydroguaiaretic acid
adhesion
blood and hemopoietic system
cardiovascular system
controlled study
drug mechanism
drug sensitivity
human
human cell
patient
therapy
thrombocyte aggregation
thrombosis
5,8,11,14-Eicosatetraynoic Acid
Adenosine Diphosphate
Arachidonic Acid
Arachidonic Acids
Aspirin
Catechols
Collagen
Humans
Lipoxygenase Inhibitors
Nordihydroguaiaretic Acid
Platelet Adhesiveness
Platelet Aggregation
description The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983.
format JOUR
author Gimeno, M.F.
Shattner, M.A.
Borda, E.
Gimeno, A.L.
Lazzari, M.A.
author_facet Gimeno, M.F.
Shattner, M.A.
Borda, E.
Gimeno, A.L.
Lazzari, M.A.
author_sort Gimeno, M.F.
title Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_short Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_full Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_fullStr Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_full_unstemmed Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
title_sort lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
url http://hdl.handle.net/20.500.12110/paper_02621746_v11_n1_p109_Gimeno
work_keys_str_mv AT gimenomf lipoxygenaseinhibitorsalteraggregationandadhesivenessofhumanbloodplateletsfromaspirintreatedpatients
AT shattnerma lipoxygenaseinhibitorsalteraggregationandadhesivenessofhumanbloodplateletsfromaspirintreatedpatients
AT bordae lipoxygenaseinhibitorsalteraggregationandadhesivenessofhumanbloodplateletsfromaspirintreatedpatients
AT gimenoal lipoxygenaseinhibitorsalteraggregationandadhesivenessofhumanbloodplateletsfromaspirintreatedpatients
AT lazzarima lipoxygenaseinhibitorsalteraggregationandadhesivenessofhumanbloodplateletsfromaspirintreatedpatients
_version_ 1782025878453092352

Ejemplares similares