Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis

Mostrar todas las versiones(2)

Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Domínguez, R.O., Pagano, M.A., Marschoff, E.R., González, S.E., Repetto, M.G., Serra, J.A.
Formato: INPR
Lenguaje:Spanish
Materias:
Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_02134853_v_n_p_Dominguez
record_format dspace
spelling todo:paper_02134853_v_n_p_Dominguez2023-10-03T15:10:09Z Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis Domínguez, R.O. Pagano, M.A. Marschoff, E.R. González, S.E. Repetto, M.G. Serra, J.A. Alzheimer's disease Cerebral glucose metabolism Diabetes mellitus type 2 Hypoglycaemic drugs Insulin resistance Oxidative stress Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and β-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations. Conclusions: Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment. © 2013 Sociedad Española de Neurología. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR Spanish info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Spanish
orig_language_str_mv Spanish
topic Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
spellingShingle Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
Domínguez, R.O.
Pagano, M.A.
Marschoff, E.R.
González, S.E.
Repetto, M.G.
Serra, J.A.
Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
topic_facet Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
description Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and β-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations. Conclusions: Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment. © 2013 Sociedad Española de Neurología.
format INPR
author Domínguez, R.O.
Pagano, M.A.
Marschoff, E.R.
González, S.E.
Repetto, M.G.
Serra, J.A.
author_facet Domínguez, R.O.
Pagano, M.A.
Marschoff, E.R.
González, S.E.
Repetto, M.G.
Serra, J.A.
author_sort Domínguez, R.O.
title Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_short Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_full Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_fullStr Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_full_unstemmed Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_sort alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: associations and a hypothesis
url http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
work_keys_str_mv AT dominguezro alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
AT paganoma alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
AT marschoffer alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
AT gonzalezse alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
AT repettomg alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
AT serraja alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
_version_ 1807324591393079296

Ejemplares similares