Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells

External proton and 6,7Li beams, of energies around 24 and 48 MeV respectively, were produced and characterized dosimetrically at the Tandem accelerator TANDAR in Buenos Aires and used for radiobiology studies on tumor and normal cell cultures. The beam monitoring instrumentation of a dedicated beam...

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Autores principales: Schuff, J.A., Policastro, L., Durán, H., Kreiner, A.J, Mazal, A., Molinari, B.L., Burlón, A., Debray, M.E., Kesque, J.M., Somacal, H., Stoliar, P., Valda, A., Bernaola, O.A., Perez de la Hoz, A., Saint-Martin, G., O'Connor, S., Davidson, J., Davidson, M., Naab, F., Ozafrán, M.J., Vázquez, M.E., Cáneva, S., Delacroix, S., Favaudon, F., Henry, Y., Nauraye, C., Brune, E., Gautier, C., Habrand, J.L., Palmieri, M., Ruffolo, M.
Formato: JOUR
Lenguaje:English
Materias:
6,7Li ions
Cells
Dosimetry
Instrumentation
Protons
RBE
Biological radiation effects
Cell culture
Lithium
Particle accelerators
Radiotherapy
Tumors
Radiobiology
Proton beams
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0168583X_v187_n3_p345_Schuff
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0168583X_v187_n3_p345_Schuff
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spelling todo:paper_0168583X_v187_n3_p345_Schuff2023-10-03T15:06:24Z Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells Schuff, J.A. Policastro, L. Durán, H. Kreiner, A.J Mazal, A. Molinari, B.L. Burlón, A. Debray, M.E. Kesque, J.M. Somacal, H. Stoliar, P. Valda, A. Bernaola, O.A. Perez de la Hoz, A. Saint-Martin, G. O'Connor, S. Davidson, J. Davidson, M. Naab, F. Ozafrán, M.J. Vázquez, M.E. Cáneva, S. Delacroix, S. Favaudon, F. Henry, Y. Nauraye, C. Brune, E. Gautier, C. Habrand, J.L. Palmieri, M. Ruffolo, M. 6,7Li ions Cells Dosimetry Instrumentation Protons RBE Biological radiation effects Cell culture Dosimetry Lithium Particle accelerators Radiotherapy Tumors Radiobiology Proton beams External proton and 6,7Li beams, of energies around 24 and 48 MeV respectively, were produced and characterized dosimetrically at the Tandem accelerator TANDAR in Buenos Aires and used for radiobiology studies on tumor and normal cell cultures. The beam monitoring instrumentation of a dedicated beam line is discussed. Relative biological effectiveness (RBE) values (at 10% survival) have been measured as functions of projectile energy (0-21 MeV) for protons and 6,7Li ions for different tumor (PDV, PDVC57) and reference cell lines (V79). The RBE values for these cell lines have been determined here for the first time but are similar to those reported in the literature for other cell lines. © 2002 Elsevier Science B.V. All rights reserved. Fil:Schuff, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Policastro, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Durán, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kreiner, A.J Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Molinari, B.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burlón, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Debray, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Somacal, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Saint-Martin, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:O'Connor, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Davidson, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Davidson, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cáneva, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Palmieri, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0168583X_v187_n3_p345_Schuff
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic 6,7Li ions
Cells
Dosimetry
Instrumentation
Protons
RBE
Biological radiation effects
Cell culture
Dosimetry
Lithium
Particle accelerators
Radiotherapy
Tumors
Radiobiology
Proton beams
spellingShingle 6,7Li ions
Cells
Dosimetry
Instrumentation
Protons
RBE
Biological radiation effects
Cell culture
Dosimetry
Lithium
Particle accelerators
Radiotherapy
Tumors
Radiobiology
Proton beams
Schuff, J.A.
Policastro, L.
Durán, H.
Kreiner, A.J
Mazal, A.
Molinari, B.L.
Burlón, A.
Debray, M.E.
Kesque, J.M.
Somacal, H.
Stoliar, P.
Valda, A.
Bernaola, O.A.
Perez de la Hoz, A.
Saint-Martin, G.
O'Connor, S.
Davidson, J.
Davidson, M.
Naab, F.
Ozafrán, M.J.
Vázquez, M.E.
Cáneva, S.
Delacroix, S.
Favaudon, F.
Henry, Y.
Nauraye, C.
Brune, E.
Gautier, C.
Habrand, J.L.
Palmieri, M.
Ruffolo, M.
Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
topic_facet 6,7Li ions
Cells
Dosimetry
Instrumentation
Protons
RBE
Biological radiation effects
Cell culture
Dosimetry
Lithium
Particle accelerators
Radiotherapy
Tumors
Radiobiology
Proton beams
description External proton and 6,7Li beams, of energies around 24 and 48 MeV respectively, were produced and characterized dosimetrically at the Tandem accelerator TANDAR in Buenos Aires and used for radiobiology studies on tumor and normal cell cultures. The beam monitoring instrumentation of a dedicated beam line is discussed. Relative biological effectiveness (RBE) values (at 10% survival) have been measured as functions of projectile energy (0-21 MeV) for protons and 6,7Li ions for different tumor (PDV, PDVC57) and reference cell lines (V79). The RBE values for these cell lines have been determined here for the first time but are similar to those reported in the literature for other cell lines. © 2002 Elsevier Science B.V. All rights reserved.
format JOUR
author Schuff, J.A.
Policastro, L.
Durán, H.
Kreiner, A.J
Mazal, A.
Molinari, B.L.
Burlón, A.
Debray, M.E.
Kesque, J.M.
Somacal, H.
Stoliar, P.
Valda, A.
Bernaola, O.A.
Perez de la Hoz, A.
Saint-Martin, G.
O'Connor, S.
Davidson, J.
Davidson, M.
Naab, F.
Ozafrán, M.J.
Vázquez, M.E.
Cáneva, S.
Delacroix, S.
Favaudon, F.
Henry, Y.
Nauraye, C.
Brune, E.
Gautier, C.
Habrand, J.L.
Palmieri, M.
Ruffolo, M.
author_facet Schuff, J.A.
Policastro, L.
Durán, H.
Kreiner, A.J
Mazal, A.
Molinari, B.L.
Burlón, A.
Debray, M.E.
Kesque, J.M.
Somacal, H.
Stoliar, P.
Valda, A.
Bernaola, O.A.
Perez de la Hoz, A.
Saint-Martin, G.
O'Connor, S.
Davidson, J.
Davidson, M.
Naab, F.
Ozafrán, M.J.
Vázquez, M.E.
Cáneva, S.
Delacroix, S.
Favaudon, F.
Henry, Y.
Nauraye, C.
Brune, E.
Gautier, C.
Habrand, J.L.
Palmieri, M.
Ruffolo, M.
author_sort Schuff, J.A.
title Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
title_short Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
title_full Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
title_fullStr Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
title_full_unstemmed Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
title_sort relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells
url http://hdl.handle.net/20.500.12110/paper_0168583X_v187_n3_p345_Schuff
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