Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices

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The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave inf...

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Autores principales:	François, N.J., Rojas, A.M., Daraio, M.E., Bernik, D.L.
Formato:	JOUR
Materias:	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01683659_v90_n3_p355_Francois
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spelling	todo:paper_01683659_v90_n3_p355_Francois2023-10-03T15:06:22Z Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices François, N.J. Rojas, A.M. Daraio, M.E. Bernik, D.L. Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile. © 2003 Elsevier B.V. All rights reserved. Fil:Rojas, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bernik, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
spellingShingle	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity François, N.J. Rojas, A.M. Daraio, M.E. Bernik, D.L. Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
topic_facet	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
description	The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile. © 2003 Elsevier B.V. All rights reserved.
format	JOUR
author	François, N.J. Rojas, A.M. Daraio, M.E. Bernik, D.L.
author_facet	François, N.J. Rojas, A.M. Daraio, M.E. Bernik, D.L.
author_sort	François, N.J.
title	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_short	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_full	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_fullStr	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_full_unstemmed	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_sort	dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
url	http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
work_keys_str_mv	AT francoisnj dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices AT rojasam dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices AT daraiome dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices AT bernikdl dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices
_version_	1807317907300941824

Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices

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