Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro

In the present paper the in vitro antiviral activity of dehydroepiandrosterone (DHEA), epiandrosterone (EA) and 16 synthetic derivatives against Junin virus (JUNV) replication in Vero cells was studied. DHEA and EA caused a selective inhibition of the replication of JUNV and other members of the Are...

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Detalles Bibliográficos
Autores principales:	Acosta, E.G., Bruttomesso, A.C., Bisceglia, J.A., Wachsman, M.B., Galagovsky, L.R., Castilla, V.
Formato:	JOUR
Materias:	Antiviral activity Arenavirus Dehydroepiandrosterone DHEA Junin virus Steroid 17 oxo 5alpha androstan 3beta yl acetate 17 oxo 5alpha androstan 3beta,16beta yl diacetate 17 oxo 5alpha androstan 5 en 3beta,16alpha yl diacetate 17 oxoandrost 5 en 3beta yl acetate 17 oxoandrost 5 en 3beta,16alpha yl diacetate 17 oxoandrost 5 en 3beta,16beta yl diacetate 17,17 ethylendioxy 3beta androstanol 17,17 ethylendioxy 3beta androstanyl acetate 17,17 ethylendioxy 3beta,6alpha androstanediol 17,17 ethylendioxyandrost 15 en 3beta ol 17,17 ethylendioxyandrost 5 en 3beta ol 3beta 6alpha dihydroxy 17 androstanone 3beta hydroxyandrost 15 en 17 one 3beta,15alpha dihydroxy 5alpha androstan 17 one 3beta,15beta dihydroxy 5alpha androstan 17 one 3beta,16alpha dihydroxy 5alpha androstan 17 one epiandrosterone glycoprotein g1 prasterone ribavirin virus protein animal cell antiviral activity article controlled study cytotoxicity drug inhibition in vitro study nonhuman Pichinde arenavirus priority journal protein synthesis Vero cell virus particle virus replication virus transcription Androsterone Animals Antiviral Agents Cercopithecus aethiops Structure-Activity Relationship Vero Cells Viral Proteins Virus Replication Arenaviridae Pichinde virus Tacaribe virus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01681702_v135_n2_p203_Acosta
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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