Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor
The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin ex...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover |
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todo:paper_01676806_v19_n1_p47_Bover2023-10-03T15:05:05Z Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor Bover, L. Barrio, M. Slavutsky, I. Bravo, A.I. Quintans, C. Bagnati, A. Lema, B. Schiaffi, J. Yomha, R. Mordoh, J. breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs). © 1991 Kluwer Academic Publishers. Fil:Bover, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barrio, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured |
| spellingShingle |
breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured Bover, L. Barrio, M. Slavutsky, I. Bravo, A.I. Quintans, C. Bagnati, A. Lema, B. Schiaffi, J. Yomha, R. Mordoh, J. Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| topic_facet |
breast cancer cell line cytogenetics morphology article breast cancer chromosome aberration female human human cell tumor cell line undifferentiated carcinoma Animal Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Cell Differentiation Cell Division Comparative Study Culture Media Female Human Immunohistochemistry Karyotyping Kinetics Mammary Neoplasms, Experimental Menopause Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface Support, Non-U.S. Gov't Tumor Cells, Cultured |
| description |
The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs). © 1991 Kluwer Academic Publishers. |
| format |
JOUR |
| author |
Bover, L. Barrio, M. Slavutsky, I. Bravo, A.I. Quintans, C. Bagnati, A. Lema, B. Schiaffi, J. Yomha, R. Mordoh, J. |
| author_facet |
Bover, L. Barrio, M. Slavutsky, I. Bravo, A.I. Quintans, C. Bagnati, A. Lema, B. Schiaffi, J. Yomha, R. Mordoh, J. |
| author_sort |
Bover, L. |
| title |
Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| title_short |
Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| title_full |
Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| title_fullStr |
Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| title_full_unstemmed |
Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor |
| title_sort |
description of a new human breast cancer cell line, iib-br-g, established from a primary undifferentiated tumor |
| url |
http://hdl.handle.net/20.500.12110/paper_01676806_v19_n1_p47_Bover |
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