Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever
Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than L...
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todo:paper_01663542_v92_n2_p125_Zapata2023-10-03T15:03:53Z Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever Zapata, J.C. Pauza, C.D. Djavani, M.M. Rodas, J.D. Moshkoff, D. Bryant, J. Ateh, E. Garcia, C. Lukashevich, I.S. Salvato, M.S. Arenaviruses Lassa fever virus LCMV Monkey models Rhesus macaques Viral hemorrhagic fever 1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine 2 morpholino 8 phenylchromone 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide alanine aminotransferase angiopeptin antivirus agent aspartate aminotransferase bavituximab benzimidazole bryostatin etanercept f 100g 5 favipiravir genistein interleukin 6 isoniazid lj 001 methyl beta cyclodextrin monoclonal antibody octreotide ribavirin rofecoxib st 193 st 294 telmisartan thalidomide unclassified drug antiviral activity antiviral therapy arenavirus infection bleeding blood clotting disorder capillary leak syndrome Chlorocebus dehydration erythema gene expression headache heart arrest histopathology host human hypertransaminasemia inflammatory infiltrate influenza Lassa fever liver necrosis lung edema Lymphocytic choriomeningitis virus lymphocytic infiltration Macaca Macaca mulatta muscle stiffness nausea nonhuman petechia photophobia priority journal respiratory distress review rhesus monkey seroprevalence teratogenicity third trimester pregnancy thrombocytopenia virus hemorrhagic fever virus load virus morphology virus replication virus titration virus virulence Animals Arenaviridae Infections Disease Models, Animal Humans Lassa Fever Lymphocytic choriomeningitis virus Macaca mulatta Lassa virus Lymphocytic choriomeningitis virus Macaca Macaca mulatta Primates Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV-infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets. © 2011 Elsevier B.V. Fil:Garcia, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01663542_v92_n2_p125_Zapata |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Arenaviruses Lassa fever virus LCMV Monkey models Rhesus macaques Viral hemorrhagic fever 1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine 2 morpholino 8 phenylchromone 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide alanine aminotransferase angiopeptin antivirus agent aspartate aminotransferase bavituximab benzimidazole bryostatin etanercept f 100g 5 favipiravir genistein interleukin 6 isoniazid lj 001 methyl beta cyclodextrin monoclonal antibody octreotide ribavirin rofecoxib st 193 st 294 telmisartan thalidomide unclassified drug antiviral activity antiviral therapy arenavirus infection bleeding blood clotting disorder capillary leak syndrome Chlorocebus dehydration erythema gene expression headache heart arrest histopathology host human hypertransaminasemia inflammatory infiltrate influenza Lassa fever liver necrosis lung edema Lymphocytic choriomeningitis virus lymphocytic infiltration Macaca Macaca mulatta muscle stiffness nausea nonhuman petechia photophobia priority journal respiratory distress review rhesus monkey seroprevalence teratogenicity third trimester pregnancy thrombocytopenia virus hemorrhagic fever virus load virus morphology virus replication virus titration virus virulence Animals Arenaviridae Infections Disease Models, Animal Humans Lassa Fever Lymphocytic choriomeningitis virus Macaca mulatta Lassa virus Lymphocytic choriomeningitis virus Macaca Macaca mulatta Primates |
| spellingShingle |
Arenaviruses Lassa fever virus LCMV Monkey models Rhesus macaques Viral hemorrhagic fever 1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine 2 morpholino 8 phenylchromone 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide alanine aminotransferase angiopeptin antivirus agent aspartate aminotransferase bavituximab benzimidazole bryostatin etanercept f 100g 5 favipiravir genistein interleukin 6 isoniazid lj 001 methyl beta cyclodextrin monoclonal antibody octreotide ribavirin rofecoxib st 193 st 294 telmisartan thalidomide unclassified drug antiviral activity antiviral therapy arenavirus infection bleeding blood clotting disorder capillary leak syndrome Chlorocebus dehydration erythema gene expression headache heart arrest histopathology host human hypertransaminasemia inflammatory infiltrate influenza Lassa fever liver necrosis lung edema Lymphocytic choriomeningitis virus lymphocytic infiltration Macaca Macaca mulatta muscle stiffness nausea nonhuman petechia photophobia priority journal respiratory distress review rhesus monkey seroprevalence teratogenicity third trimester pregnancy thrombocytopenia virus hemorrhagic fever virus load virus morphology virus replication virus titration virus virulence Animals Arenaviridae Infections Disease Models, Animal Humans Lassa Fever Lymphocytic choriomeningitis virus Macaca mulatta Lassa virus Lymphocytic choriomeningitis virus Macaca Macaca mulatta Primates Zapata, J.C. Pauza, C.D. Djavani, M.M. Rodas, J.D. Moshkoff, D. Bryant, J. Ateh, E. Garcia, C. Lukashevich, I.S. Salvato, M.S. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| topic_facet |
Arenaviruses Lassa fever virus LCMV Monkey models Rhesus macaques Viral hemorrhagic fever 1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine 2 morpholino 8 phenylchromone 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide alanine aminotransferase angiopeptin antivirus agent aspartate aminotransferase bavituximab benzimidazole bryostatin etanercept f 100g 5 favipiravir genistein interleukin 6 isoniazid lj 001 methyl beta cyclodextrin monoclonal antibody octreotide ribavirin rofecoxib st 193 st 294 telmisartan thalidomide unclassified drug antiviral activity antiviral therapy arenavirus infection bleeding blood clotting disorder capillary leak syndrome Chlorocebus dehydration erythema gene expression headache heart arrest histopathology host human hypertransaminasemia inflammatory infiltrate influenza Lassa fever liver necrosis lung edema Lymphocytic choriomeningitis virus lymphocytic infiltration Macaca Macaca mulatta muscle stiffness nausea nonhuman petechia photophobia priority journal respiratory distress review rhesus monkey seroprevalence teratogenicity third trimester pregnancy thrombocytopenia virus hemorrhagic fever virus load virus morphology virus replication virus titration virus virulence Animals Arenaviridae Infections Disease Models, Animal Humans Lassa Fever Lymphocytic choriomeningitis virus Macaca mulatta Lassa virus Lymphocytic choriomeningitis virus Macaca Macaca mulatta Primates |
| description |
Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV-infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets. © 2011 Elsevier B.V. |
| format |
JOUR |
| author |
Zapata, J.C. Pauza, C.D. Djavani, M.M. Rodas, J.D. Moshkoff, D. Bryant, J. Ateh, E. Garcia, C. Lukashevich, I.S. Salvato, M.S. |
| author_facet |
Zapata, J.C. Pauza, C.D. Djavani, M.M. Rodas, J.D. Moshkoff, D. Bryant, J. Ateh, E. Garcia, C. Lukashevich, I.S. Salvato, M.S. |
| author_sort |
Zapata, J.C. |
| title |
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| title_short |
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| title_full |
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| title_fullStr |
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| title_full_unstemmed |
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever |
| title_sort |
lymphocytic choriomeningitis virus (lcmv) infection of macaques: a model for lassa fever |
| url |
http://hdl.handle.net/20.500.12110/paper_01663542_v92_n2_p125_Zapata |
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