Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice

The autoimmune sialadenitis developed by non-obese diabetic (NOD) mice is considered a suitable model to study the ethiopathogenic mechanisms leading to sicca symptoms in Sjögren's syndrome (SS). Evidence supporting a neural rather than immune origin of the secretory dysfunction has been provid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rosignoli, F., Pérez Leirós, C.
Formato:	JOUR
Materias:	Autoimmune sialadenitis Nitric oxide NOD mice NOS isoforms Salivary glands VIP signaling amylase nitric oxide synthase vasoactive intestinal polypeptide amylase release animal experiment animal model animal tissue article controlled study diabetes mellitus enzyme activation enzyme activity enzyme release immune system inflammation mouse nervous system nonhuman parotid gland pathogenesis priority journal protein deficiency protein expression protein secretion saliva level salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Age Factors Animals Female Male Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type I Parasympathetic Fibers, Postganglionic Protein Isoforms Receptors, Muscarinic Saliva Salivary Glands Signal Transduction Sjogren's Syndrome Vasoactive Intestinal Peptide
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01655728_v130_n1-2_p109_Rosignoli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01655728_v130_n1-2_p109_Rosignoli
record_format	dspace
spelling	todo:paper_01655728_v130_n1-2_p109_Rosignoli2023-10-03T15:02:56Z Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice Rosignoli, F. Pérez Leirós, C. Autoimmune sialadenitis Nitric oxide NOD mice NOS isoforms Salivary glands VIP signaling amylase nitric oxide synthase vasoactive intestinal polypeptide amylase release animal experiment animal model animal tissue article controlled study diabetes mellitus enzyme activation enzyme activity enzyme release immune system inflammation mouse nervous system nonhuman parotid gland pathogenesis priority journal protein deficiency protein expression protein secretion saliva level salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Age Factors Animals Female Male Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type I Parasympathetic Fibers, Postganglionic Protein Isoforms Receptors, Muscarinic Saliva Salivary Glands Signal Transduction Sjogren's Syndrome Vasoactive Intestinal Peptide The autoimmune sialadenitis developed by non-obese diabetic (NOD) mice is considered a suitable model to study the ethiopathogenic mechanisms leading to sicca symptoms in Sjögren's syndrome (SS). Evidence supporting a neural rather than immune origin of the secretory dysfunction has been provided. As both nitric oxide and vasoactive intestinal peptide (VIP) are common messengers to nervous and immune systems mediating secretory and inflammatory responses, we examined nitric oxide synthase (NOS) activity with special focus on VIP-mediated effects in salivary glands of NOD mice. We found a decreased NOS activity and expression in major salivary glands of NOD mice with respect to control mice. In addition, there was a deficient VIP-activated signaling associated with a reduced saliva and amylase secretion in response to VIP. Our results support the hypothesis of an impaired balance of neuroimmune interactions in salivary glands as early events to take place in the progressive loss of secretory function of NOD mice. © 2002 Elsevier Science B.V. All rights reserved. Fil:Rosignoli, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pérez Leirós, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01655728_v130_n1-2_p109_Rosignoli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Autoimmune sialadenitis Nitric oxide NOD mice NOS isoforms Salivary glands VIP signaling amylase nitric oxide synthase vasoactive intestinal polypeptide amylase release animal experiment animal model animal tissue article controlled study diabetes mellitus enzyme activation enzyme activity enzyme release immune system inflammation mouse nervous system nonhuman parotid gland pathogenesis priority journal protein deficiency protein expression protein secretion saliva level salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Age Factors Animals Female Male Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type I Parasympathetic Fibers, Postganglionic Protein Isoforms Receptors, Muscarinic Saliva Salivary Glands Signal Transduction Sjogren's Syndrome Vasoactive Intestinal Peptide
spellingShingle	Autoimmune sialadenitis Nitric oxide NOD mice NOS isoforms Salivary glands VIP signaling amylase nitric oxide synthase vasoactive intestinal polypeptide amylase release animal experiment animal model animal tissue article controlled study diabetes mellitus enzyme activation enzyme activity enzyme release immune system inflammation mouse nervous system nonhuman parotid gland pathogenesis priority journal protein deficiency protein expression protein secretion saliva level salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Age Factors Animals Female Male Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type I Parasympathetic Fibers, Postganglionic Protein Isoforms Receptors, Muscarinic Saliva Salivary Glands Signal Transduction Sjogren's Syndrome Vasoactive Intestinal Peptide Rosignoli, F. Pérez Leirós, C. Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
topic_facet	Autoimmune sialadenitis Nitric oxide NOD mice NOS isoforms Salivary glands VIP signaling amylase nitric oxide synthase vasoactive intestinal polypeptide amylase release animal experiment animal model animal tissue article controlled study diabetes mellitus enzyme activation enzyme activity enzyme release immune system inflammation mouse nervous system nonhuman parotid gland pathogenesis priority journal protein deficiency protein expression protein secretion saliva level salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Age Factors Animals Female Male Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type I Parasympathetic Fibers, Postganglionic Protein Isoforms Receptors, Muscarinic Saliva Salivary Glands Signal Transduction Sjogren's Syndrome Vasoactive Intestinal Peptide
description	The autoimmune sialadenitis developed by non-obese diabetic (NOD) mice is considered a suitable model to study the ethiopathogenic mechanisms leading to sicca symptoms in Sjögren's syndrome (SS). Evidence supporting a neural rather than immune origin of the secretory dysfunction has been provided. As both nitric oxide and vasoactive intestinal peptide (VIP) are common messengers to nervous and immune systems mediating secretory and inflammatory responses, we examined nitric oxide synthase (NOS) activity with special focus on VIP-mediated effects in salivary glands of NOD mice. We found a decreased NOS activity and expression in major salivary glands of NOD mice with respect to control mice. In addition, there was a deficient VIP-activated signaling associated with a reduced saliva and amylase secretion in response to VIP. Our results support the hypothesis of an impaired balance of neuroimmune interactions in salivary glands as early events to take place in the progressive loss of secretory function of NOD mice. © 2002 Elsevier Science B.V. All rights reserved.
format	JOUR
author	Rosignoli, F. Pérez Leirós, C.
author_facet	Rosignoli, F. Pérez Leirós, C.
author_sort	Rosignoli, F.
title	Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
title_short	Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
title_full	Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
title_fullStr	Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
title_full_unstemmed	Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
title_sort	nitric oxide synthase i and vip-activated signaling are affected in salivary glands of nod mice
url	http://hdl.handle.net/20.500.12110/paper_01655728_v130_n1-2_p109_Rosignoli
work_keys_str_mv	AT rosignolif nitricoxidesynthaseiandvipactivatedsignalingareaffectedinsalivaryglandsofnodmice AT perezleirosc nitricoxidesynthaseiandvipactivatedsignalingareaffectedinsalivaryglandsofnodmice
_version_	1807321476457562112

Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice

Ejemplares similares