Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida |
| Aporte de: |
| id |
todo:paper_01633864_v73_n10_p1714_RojoDeAlmeida |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_01633864_v73_n10_p1714_RojoDeAlmeida2023-10-03T15:02:17Z Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica Rojo De Almeida, M.T. Siless, G.E. Perez, C.D. Veloso, M.J. Schejter, L. Puricelli, L. Palermo, J.A. 2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations. © 2010 The American Chemical Society and American Society of Pharmacognosy. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms |
| spellingShingle |
2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms Rojo De Almeida, M.T. Siless, G.E. Perez, C.D. Veloso, M.J. Schejter, L. Puricelli, L. Palermo, J.A. Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| topic_facet |
2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms |
| description |
Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations. © 2010 The American Chemical Society and American Society of Pharmacognosy. |
| format |
JOUR |
| author |
Rojo De Almeida, M.T. Siless, G.E. Perez, C.D. Veloso, M.J. Schejter, L. Puricelli, L. Palermo, J.A. |
| author_facet |
Rojo De Almeida, M.T. Siless, G.E. Perez, C.D. Veloso, M.J. Schejter, L. Puricelli, L. Palermo, J.A. |
| author_sort |
Rojo De Almeida, M.T. |
| title |
Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| title_short |
Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| title_full |
Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| title_fullStr |
Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| title_full_unstemmed |
Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| title_sort |
dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| url |
http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida |
| work_keys_str_mv |
AT rojodealmeidamt dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT silessge dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT perezcd dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT velosomj dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT schejterl dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT puricellil dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica AT palermoja dolabellanediterpenoidsfromthesouthatlanticgorgonianconvexellamagelhaenica |
| _version_ |
1807322159761063936 |