15,21-Cyclowithanolides from Jaborosa bergii

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Six new withanolides (1-6) were isolated from the aerial parts of Jaborosa bergii plants and characterized by spectroscopic methods (1D and 2D NMR, MS). Five of the new compounds presented a novel norbornane-type structure in ring D of the steroid nucleus (1-5), resulting from a carbon-carbon bond b...

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Autores principales:	Nicotra, V.E., Gil, R.R., Vaccarini, C., Oberti, J.C., Burton, G.
Formato:	JOUR
Materias:	15,21 cyclowithanolide derivative 2,3 dehydrojaborosalactol drug derivative ergosterol lactone derivative phytosterol unclassified drug withanolide angiosperm Argentina article carbon nuclear magnetic resonance chemical structure chemistry dose response drug isolation higher plant isolation and purification Jaborosa bergii medicinal plant nonhuman nuclear magnetic resonance phytochemistry phytotoxicity stereoisomerism sterol analysis Dose-Response Relationship, Drug Ergosterol Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Solanaceae Stereoisomerism Embryophyta Jaborosa Magnoliophyta
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01633864_v66_n11_p1471_Nicotra
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01633864_v66_n11_p1471_Nicotra
record_format	dspace
spelling	todo:paper_01633864_v66_n11_p1471_Nicotra2023-10-03T15:02:14Z 15,21-Cyclowithanolides from Jaborosa bergii Nicotra, V.E. Gil, R.R. Vaccarini, C. Oberti, J.C. Burton, G. 15,21 cyclowithanolide derivative 2,3 dehydrojaborosalactol drug derivative ergosterol lactone derivative phytosterol unclassified drug withanolide angiosperm Argentina article carbon nuclear magnetic resonance chemical structure chemistry dose response drug isolation higher plant isolation and purification Jaborosa bergii medicinal plant nonhuman nuclear magnetic resonance phytochemistry phytotoxicity stereoisomerism sterol analysis Argentina Dose-Response Relationship, Drug Ergosterol Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Solanaceae Stereoisomerism Embryophyta Jaborosa Magnoliophyta Six new withanolides (1-6) were isolated from the aerial parts of Jaborosa bergii plants and characterized by spectroscopic methods (1D and 2D NMR, MS). Five of the new compounds presented a novel norbornane-type structure in ring D of the steroid nucleus (1-5), resulting from a carbon-carbon bond between C-15 and C-21. The sixth withanolide isolated was the 5α-chloro-6β -hydroxy analogue (6) of 2,3-dehydrojaborosalactol M (7), previously isolated from this plant. Compound 1 showed selective phytotoxicity toward monocotiledoneous and dicotiledoneous species. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v66_n11_p1471_Nicotra
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	15,21 cyclowithanolide derivative 2,3 dehydrojaborosalactol drug derivative ergosterol lactone derivative phytosterol unclassified drug withanolide angiosperm Argentina article carbon nuclear magnetic resonance chemical structure chemistry dose response drug isolation higher plant isolation and purification Jaborosa bergii medicinal plant nonhuman nuclear magnetic resonance phytochemistry phytotoxicity stereoisomerism sterol analysis Argentina Dose-Response Relationship, Drug Ergosterol Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Solanaceae Stereoisomerism Embryophyta Jaborosa Magnoliophyta
spellingShingle	15,21 cyclowithanolide derivative 2,3 dehydrojaborosalactol drug derivative ergosterol lactone derivative phytosterol unclassified drug withanolide angiosperm Argentina article carbon nuclear magnetic resonance chemical structure chemistry dose response drug isolation higher plant isolation and purification Jaborosa bergii medicinal plant nonhuman nuclear magnetic resonance phytochemistry phytotoxicity stereoisomerism sterol analysis Argentina Dose-Response Relationship, Drug Ergosterol Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Solanaceae Stereoisomerism Embryophyta Jaborosa Magnoliophyta Nicotra, V.E. Gil, R.R. Vaccarini, C. Oberti, J.C. Burton, G. 15,21-Cyclowithanolides from Jaborosa bergii
topic_facet	15,21 cyclowithanolide derivative 2,3 dehydrojaborosalactol drug derivative ergosterol lactone derivative phytosterol unclassified drug withanolide angiosperm Argentina article carbon nuclear magnetic resonance chemical structure chemistry dose response drug isolation higher plant isolation and purification Jaborosa bergii medicinal plant nonhuman nuclear magnetic resonance phytochemistry phytotoxicity stereoisomerism sterol analysis Argentina Dose-Response Relationship, Drug Ergosterol Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Solanaceae Stereoisomerism Embryophyta Jaborosa Magnoliophyta
description	Six new withanolides (1-6) were isolated from the aerial parts of Jaborosa bergii plants and characterized by spectroscopic methods (1D and 2D NMR, MS). Five of the new compounds presented a novel norbornane-type structure in ring D of the steroid nucleus (1-5), resulting from a carbon-carbon bond between C-15 and C-21. The sixth withanolide isolated was the 5α-chloro-6β -hydroxy analogue (6) of 2,3-dehydrojaborosalactol M (7), previously isolated from this plant. Compound 1 showed selective phytotoxicity toward monocotiledoneous and dicotiledoneous species.
format	JOUR
author	Nicotra, V.E. Gil, R.R. Vaccarini, C. Oberti, J.C. Burton, G.
author_facet	Nicotra, V.E. Gil, R.R. Vaccarini, C. Oberti, J.C. Burton, G.
author_sort	Nicotra, V.E.
title	15,21-Cyclowithanolides from Jaborosa bergii
title_short	15,21-Cyclowithanolides from Jaborosa bergii
title_full	15,21-Cyclowithanolides from Jaborosa bergii
title_fullStr	15,21-Cyclowithanolides from Jaborosa bergii
title_full_unstemmed	15,21-Cyclowithanolides from Jaborosa bergii
title_sort	15,21-cyclowithanolides from jaborosa bergii
url	http://hdl.handle.net/20.500.12110/paper_01633864_v66_n11_p1471_Nicotra
work_keys_str_mv	AT nicotrave 1521cyclowithanolidesfromjaborosabergii AT gilrr 1521cyclowithanolidesfromjaborosabergii AT vaccarinic 1521cyclowithanolidesfromjaborosabergii AT obertijc 1521cyclowithanolidesfromjaborosabergii AT burtong 1521cyclowithanolidesfromjaborosabergii
_version_	1807314593529200640

15,21-Cyclowithanolides from Jaborosa bergii

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