Induction of quinone reductase by withanolides
Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico |
| Aporte de: |
| id |
todo:paper_01633864_v65_n5_p677_Misico |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_01633864_v65_n5_p677_Misico2023-10-03T15:02:13Z Induction of quinone reductase by withanolides Misico, R.I. Song, L.L. Veleiro, A.S. Cirigliano, A.M. Tettamanzi, M.C. Burton, G. Bonetto, G.M. Nicotra, V.E. Silva, G.L. Gil, R.R. Oberti, J.C. Kinghorn, A.D. Pezzuto, J.M. 18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cirigliano, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tettamanzi, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae |
| spellingShingle |
18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae Misico, R.I. Song, L.L. Veleiro, A.S. Cirigliano, A.M. Tettamanzi, M.C. Burton, G. Bonetto, G.M. Nicotra, V.E. Silva, G.L. Gil, R.R. Oberti, J.C. Kinghorn, A.D. Pezzuto, J.M. Induction of quinone reductase by withanolides |
| topic_facet |
18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae |
| description |
Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland. |
| format |
JOUR |
| author |
Misico, R.I. Song, L.L. Veleiro, A.S. Cirigliano, A.M. Tettamanzi, M.C. Burton, G. Bonetto, G.M. Nicotra, V.E. Silva, G.L. Gil, R.R. Oberti, J.C. Kinghorn, A.D. Pezzuto, J.M. |
| author_facet |
Misico, R.I. Song, L.L. Veleiro, A.S. Cirigliano, A.M. Tettamanzi, M.C. Burton, G. Bonetto, G.M. Nicotra, V.E. Silva, G.L. Gil, R.R. Oberti, J.C. Kinghorn, A.D. Pezzuto, J.M. |
| author_sort |
Misico, R.I. |
| title |
Induction of quinone reductase by withanolides |
| title_short |
Induction of quinone reductase by withanolides |
| title_full |
Induction of quinone reductase by withanolides |
| title_fullStr |
Induction of quinone reductase by withanolides |
| title_full_unstemmed |
Induction of quinone reductase by withanolides |
| title_sort |
induction of quinone reductase by withanolides |
| url |
http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico |
| work_keys_str_mv |
AT misicori inductionofquinonereductasebywithanolides AT songll inductionofquinonereductasebywithanolides AT veleiroas inductionofquinonereductasebywithanolides AT ciriglianoam inductionofquinonereductasebywithanolides AT tettamanzimc inductionofquinonereductasebywithanolides AT burtong inductionofquinonereductasebywithanolides AT bonettogm inductionofquinonereductasebywithanolides AT nicotrave inductionofquinonereductasebywithanolides AT silvagl inductionofquinonereductasebywithanolides AT gilrr inductionofquinonereductasebywithanolides AT obertijc inductionofquinonereductasebywithanolides AT kinghornad inductionofquinonereductasebywithanolides AT pezzutojm inductionofquinonereductasebywithanolides |
| _version_ |
1807316416600211456 |