Withanolides from Vassobia lorentzii

Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epox...

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Autores principales:	Misico, R.I., Gil, R.R., Oberti, J.C., Veleiro, A.S., Burton, G.
Formato:	JOUR
Materias:	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01633864_v63_n10_p1329_Misico
record_format	dspace
spelling	todo:paper_01633864_v63_n10_p1329_Misico2023-10-03T15:02:11Z Withanolides from Vassobia lorentzii Misico, R.I. Gil, R.R. Oberti, J.C. Veleiro, A.S. Burton, G. 18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
spellingShingle	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia Misico, R.I. Gil, R.R. Oberti, J.C. Veleiro, A.S. Burton, G. Withanolides from Vassobia lorentzii
topic_facet	18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide plant extract unclassified drug Vassobia lorentzii extract withanolide article chemical structure chemotaxonomy extraction isomer molecular model nonhuman spectroscopy Animals Antimalarials Ergosterol Humans Lactones Magnetic Resonance Spectroscopy Plasmodium falciparum Solanaceae Vassobia
description	Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18.
format	JOUR
author	Misico, R.I. Gil, R.R. Oberti, J.C. Veleiro, A.S. Burton, G.
author_facet	Misico, R.I. Gil, R.R. Oberti, J.C. Veleiro, A.S. Burton, G.
author_sort	Misico, R.I.
title	Withanolides from Vassobia lorentzii
title_short	Withanolides from Vassobia lorentzii
title_full	Withanolides from Vassobia lorentzii
title_fullStr	Withanolides from Vassobia lorentzii
title_full_unstemmed	Withanolides from Vassobia lorentzii
title_sort	withanolides from vassobia lorentzii
url	http://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico
work_keys_str_mv	AT misicori withanolidesfromvassobialorentzii AT gilrr withanolidesfromvassobialorentzii AT obertijc withanolidesfromvassobialorentzii AT veleiroas withanolidesfromvassobialorentzii AT burtong withanolidesfromvassobialorentzii
_version_	1807316005541642240

Withanolides from Vassobia lorentzii

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