Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus

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On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-...

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Autores principales:	Romano, A., Lozada, M., Maldonado, H.
Formato:	JOUR
Materias:	naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01631047_v53_n1_p113_Romano
record_format	dspace
spelling	todo:paper_01631047_v53_n1_p113_Romano2023-10-03T15:01:38Z Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus Romano, A. Lozada, M. Maldonado, H. naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-trial habituation session. An enhancing effect of 3.2 μg NX/g on responsiveness appeared over trials, that cannot be explained either by a ceiling effect or by a delay in peak drug action. Two doses below 3.2 μg/g and one dose above had no significant effect. Results from a second series of experiments showed that the 3.2 μg NX/g effect vanishes after 15 trials (1 h after injection). The hypothesis that crab's habitution involves the action of an endogenous opioid mechanism is put forward to account for the naloxone pretreatment effect. © 1978 Academic Press, Inc. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lozada, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't
spellingShingle	naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't Romano, A. Lozada, M. Maldonado, H. Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
topic_facet	naloxone amphibia animal experiment arthropod article behavior conditioning crab habituation nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Fear Habituation (Psychophysiology) Male Naloxone Receptors, Opioid Support, Non-U.S. Gov't
description	On sudden presentation of a passing shadow, the crab Chasmagnathus granulatus reacts with an escape response that habituates after repeating the same stimulus. In a first series of experiments, a range of naloxone (NX) doses (0.8, 2.4, 3.2, and 6.2 μg/g) was injected into crabs 15 min before one 15-trial habituation session. An enhancing effect of 3.2 μg NX/g on responsiveness appeared over trials, that cannot be explained either by a ceiling effect or by a delay in peak drug action. Two doses below 3.2 μg/g and one dose above had no significant effect. Results from a second series of experiments showed that the 3.2 μg NX/g effect vanishes after 15 trials (1 h after injection). The hypothesis that crab's habitution involves the action of an endogenous opioid mechanism is put forward to account for the naloxone pretreatment effect. © 1978 Academic Press, Inc.
format	JOUR
author	Romano, A. Lozada, M. Maldonado, H.
author_facet	Romano, A. Lozada, M. Maldonado, H.
author_sort	Romano, A.
title	Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
title_short	Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
title_full	Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
title_fullStr	Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
title_full_unstemmed	Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
title_sort	effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus
url	http://hdl.handle.net/20.500.12110/paper_01631047_v53_n1_p113_Romano
work_keys_str_mv	AT romanoa effectofnaloxonepretreatmentonhabituationinthecrabchasmagnathusgranulatus AT lozadam effectofnaloxonepretreatmentonhabituationinthecrabchasmagnathusgranulatus AT maldonadoh effectofnaloxonepretreatmentonhabituationinthecrabchasmagnathusgranulatus
_version_	1807316910764720128

Effect of naloxone pretreatment on habituation in the crab chasmagnathus granulatus

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