A caged nicotine with nanosecond range kinetics and visible light sensitivity

We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with...

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Detalles Bibliográficos
Autores principales: Filevich, O., Salierno, M., Etchenique, R.
Formato: JOUR
Materias:
Caged compound
Leech
NAChR
Neurotransmitter
Nicotine
Ruthenium complex
bipyridine
caged nicotine
nicotine
ruthenium
unclassified drug
article
complex formation
controlled study
cyclic potentiometry
irradiation
kinetics
leech
nonhuman
nuclear magnetic resonance spectroscopy
photolysis
quantum yield
synthesis
ultraviolet spectroscopy
Animals
Electrophysiology
Leeches
Light
Magnetic Resonance Spectroscopy
Models, Chemical
Neurons
Photochemistry
Photolysis
Ruthenium
Hirudinida
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc.

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