A caged nicotine with nanosecond range kinetics and visible light sensitivity

We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with...

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Autores principales:	Filevich, O., Salierno, M., Etchenique, R.
Formato:	JOUR
Materias:	Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Photochemistry Photolysis Ruthenium Hirudinida
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01620134_v104_n12_p1248_Filevich
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spelling	todo:paper_01620134_v104_n12_p1248_Filevich2023-10-03T15:01:26Z A caged nicotine with nanosecond range kinetics and visible light sensitivity Filevich, O. Salierno, M. Etchenique, R. Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Nicotine Photochemistry Photolysis Ruthenium Hirudinida We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc. Fil:Filevich, O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salierno, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Nicotine Photochemistry Photolysis Ruthenium Hirudinida
spellingShingle	Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Nicotine Photochemistry Photolysis Ruthenium Hirudinida Filevich, O. Salierno, M. Etchenique, R. A caged nicotine with nanosecond range kinetics and visible light sensitivity
topic_facet	Caged compound Leech NAChR Neurotransmitter Nicotine Ruthenium complex bipyridine caged nicotine nicotine ruthenium unclassified drug article complex formation controlled study cyclic potentiometry irradiation kinetics leech nonhuman nuclear magnetic resonance spectroscopy photolysis quantum yield synthesis ultraviolet spectroscopy Animals Electrophysiology Leeches Light Magnetic Resonance Spectroscopy Models, Chemical Neurons Nicotine Photochemistry Photolysis Ruthenium Hirudinida
description	We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc.
format	JOUR
author	Filevich, O. Salierno, M. Etchenique, R.
author_facet	Filevich, O. Salierno, M. Etchenique, R.
author_sort	Filevich, O.
title	A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_short	A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_full	A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_fullStr	A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_full_unstemmed	A caged nicotine with nanosecond range kinetics and visible light sensitivity
title_sort	caged nicotine with nanosecond range kinetics and visible light sensitivity
url	http://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich
work_keys_str_mv	AT filevicho acagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity AT saliernom acagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity AT etcheniquer acagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity AT filevicho cagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity AT saliernom cagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity AT etcheniquer cagednicotinewithnanosecondrangekineticsandvisiblelightsensitivity
_version_	1807323588338909184

A caged nicotine with nanosecond range kinetics and visible light sensitivity

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