Hepatic damage and oxidative stress induced by griseofulvin in mice

Erythropoietic Protoporphyria (EPP) is a disease associated with ferrochelatase deficiency, which produces accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver and skin. In some cases, a severe hepatic failure and cholestasis was observed. Griseofulvin (Gris) develops an experimental...

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Detalles Bibliográficos
Autores principales: Martinez, M.D.C., Afonso, S.G., Meiss, R.P., Buzaleh, A.M., Batlle, A.
Formato: JOUR
Materias:
Erythropoietic Protoporphyria
Griseofulvin
Heme metabolism
Liver damage
Oxidative stress
5 aminolevulinate synthase
alanine aminotransferase
alkaline phosphatase
aspartate aminotransferase
catalase
cytochrome P450 1A2
cytochrome P450 2A6
cytochrome P450 2C9
cytochrome P450 2E1
cytochrome P450 3A4
glutathione
glutathione peroxidase
glutathione reductase
glutathione transferase
griseofulvin
heme
heme oxygenase
malonaldehyde
protoporphyrin
reactive oxygen metabolite
superoxide dismutase
tryptophan 2,3 dioxygenase
alanine aminotransferase blood level
alkaline phosphatase blood level
animal experiment
animal model
animal tissue
antioxidant activity
article
aspartate aminotransferase blood level
blood level
body weight
controlled study
enzyme activity
enzyme induction
erythropoietic protoporphyria
experimental mouse
feces level
histopathology
liver injury
liver level
liver weight
male
mouse
nonhuman
oxidation reduction reaction
oxidative stress
Animals
Antifungal Agents
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP3A
Disease Models, Animal
Heme
Heme Oxygenase (Decyclizing)
Immunohistochemistry
Liver
Male
Mice
Oxidative Stress
Protoporphyria, Erythropoietic
Protoporphyrins
Tryptophan Oxygenase
Animalia
Mus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01455680_v55_n2_p127_Martinez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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