Selective O-desulphation of heparin in triethylamine

Mostrar todas las versiones(2)

Alkaline desulphation of heparin has not been so extensively studied as acid hydrolysis or solvolysis. Heparin was treated with 20% triethylamine (TEA) in aqueous solution under two different sets of experimental conditions. After elimination of the base, the products (H-a and H-b) were subjected to...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fraidenraich y Waisman, D., Cirelli, A.F.
Formato: JOUR
Materias:
Chemical Reactions - Reaction Kinetics
Chromatographic Analysis - Gel Permeation
Natural Polymers - Chemical Reactions
Nuclear Magnetic Resonance
Desulfation
Heparin
Polysaccharides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01448617_v17_n2_p111_FraidenraichyWaisman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01448617_v17_n2_p111_FraidenraichyWaisman
record_format dspace
spelling todo:paper_01448617_v17_n2_p111_FraidenraichyWaisman2023-10-03T14:59:39Z Selective O-desulphation of heparin in triethylamine Fraidenraich y Waisman, D. Cirelli, A.F. Chemical Reactions - Reaction Kinetics Chromatographic Analysis - Gel Permeation Natural Polymers - Chemical Reactions Nuclear Magnetic Resonance Desulfation Heparin Polysaccharides Alkaline desulphation of heparin has not been so extensively studied as acid hydrolysis or solvolysis. Heparin was treated with 20% triethylamine (TEA) in aqueous solution under two different sets of experimental conditions. After elimination of the base, the products (H-a and H-b) were subjected to gel chromatography, analysed for total and N-sulphate content, and electrophoretic mobility and characterized by 13C-NMR spectroscopy. Selective 2-O-desulphation of L-iduronic acid residues and partial 6-O-desulphation of 2-amino-2-deoxy-D-glucose was observed, while N-sulphoamino groups remained attached. There was also spectroscopic evidence of the formation of 2,3-anhydro-L-iduronic acid moieties. © 1991. Fil:Fraidenraich y Waisman, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01448617_v17_n2_p111_FraidenraichyWaisman
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Chemical Reactions - Reaction Kinetics
Chromatographic Analysis - Gel Permeation
Natural Polymers - Chemical Reactions
Nuclear Magnetic Resonance
Desulfation
Heparin
Polysaccharides
spellingShingle Chemical Reactions - Reaction Kinetics
Chromatographic Analysis - Gel Permeation
Natural Polymers - Chemical Reactions
Nuclear Magnetic Resonance
Desulfation
Heparin
Polysaccharides
Fraidenraich y Waisman, D.
Cirelli, A.F.
Selective O-desulphation of heparin in triethylamine
topic_facet Chemical Reactions - Reaction Kinetics
Chromatographic Analysis - Gel Permeation
Natural Polymers - Chemical Reactions
Nuclear Magnetic Resonance
Desulfation
Heparin
Polysaccharides
description Alkaline desulphation of heparin has not been so extensively studied as acid hydrolysis or solvolysis. Heparin was treated with 20% triethylamine (TEA) in aqueous solution under two different sets of experimental conditions. After elimination of the base, the products (H-a and H-b) were subjected to gel chromatography, analysed for total and N-sulphate content, and electrophoretic mobility and characterized by 13C-NMR spectroscopy. Selective 2-O-desulphation of L-iduronic acid residues and partial 6-O-desulphation of 2-amino-2-deoxy-D-glucose was observed, while N-sulphoamino groups remained attached. There was also spectroscopic evidence of the formation of 2,3-anhydro-L-iduronic acid moieties. © 1991.
format JOUR
author Fraidenraich y Waisman, D.
Cirelli, A.F.
author_facet Fraidenraich y Waisman, D.
Cirelli, A.F.
author_sort Fraidenraich y Waisman, D.
title Selective O-desulphation of heparin in triethylamine
title_short Selective O-desulphation of heparin in triethylamine
title_full Selective O-desulphation of heparin in triethylamine
title_fullStr Selective O-desulphation of heparin in triethylamine
title_full_unstemmed Selective O-desulphation of heparin in triethylamine
title_sort selective o-desulphation of heparin in triethylamine
url http://hdl.handle.net/20.500.12110/paper_01448617_v17_n2_p111_FraidenraichyWaisman
work_keys_str_mv AT fraidenraichywaismand selectiveodesulphationofheparinintriethylamine
AT cirelliaf selectiveodesulphationofheparinintriethylamine
_version_ 1807314591872450560

Ejemplares similares