A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis

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We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values fo...

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Detalles Bibliográficos
Autores principales: Fraiman, D., Dawson, S.P.
Formato: JOUR
Materias:
InsP3-receptor
Luminal Ca2+
Stochastic model
calcium channel
calcium ion
inositol 1,4,5 trisphosphate receptor
calcium
cell receptor
article
binding site
calcium binding
channel gating
controlled study
cytosol
experimental model
medical literature
observation
priority journal
probability
quantitative analysis
simulation
stochastic model
calcium signaling
chemical model
chemistry
metabolism
protein binding
Binding Sites
Calcium
Calcium Channels
Calcium Signaling
Models, Chemical
Protein Binding
Receptors, Cytoplasmic and Nuclear
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01434160_v35_n5_p403_Fraiman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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