Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice

The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3...

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Autores principales: Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A.
Formato: JOUR
Materias:
estrogen receptor
medroxyprogesterone acetate
methylnitrosourea
progesterone receptor
animal experiment
animal model
animal tissue
article
breast adenocarcinoma
breast carcinogenesis
breast tumor
cell differentiation
controlled study
female
mouse
nonhuman
priority journal
promoter region
Adenocarcinoma
Animals
Carcinogens
Cocarcinogenesis
Female
Mammary Neoplasms, Experimental
Medroxyprogesterone 17-Acetate
Methylnitrosourea
Mice
Mice, Inbred BALB C
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01433334_v19_n3_p529_Pazos
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spelling todo:paper_01433334_v19_n3_p529_Pazos2023-10-03T14:59:17Z Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice Pazos, P. Lanari, C. Elizalde, P. Montecchia, F. Charreau, E.H. Molinolo, A.A. estrogen receptor medroxyprogesterone acetate methylnitrosourea progesterone receptor animal experiment animal model animal tissue article breast adenocarcinoma breast carcinogenesis breast tumor cell differentiation controlled study female mouse nonhuman priority journal promoter region Adenocarcinoma Animals Carcinogens Cocarcinogenesis Female Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic estrogen receptor
medroxyprogesterone acetate
methylnitrosourea
progesterone receptor
animal experiment
animal model
animal tissue
article
breast adenocarcinoma
breast carcinogenesis
breast tumor
cell differentiation
controlled study
female
mouse
nonhuman
priority journal
promoter region
Adenocarcinoma
Animals
Carcinogens
Cocarcinogenesis
Female
Mammary Neoplasms, Experimental
Medroxyprogesterone 17-Acetate
Methylnitrosourea
Mice
Mice, Inbred BALB C
spellingShingle estrogen receptor
medroxyprogesterone acetate
methylnitrosourea
progesterone receptor
animal experiment
animal model
animal tissue
article
breast adenocarcinoma
breast carcinogenesis
breast tumor
cell differentiation
controlled study
female
mouse
nonhuman
priority journal
promoter region
Adenocarcinoma
Animals
Carcinogens
Cocarcinogenesis
Female
Mammary Neoplasms, Experimental
Medroxyprogesterone 17-Acetate
Methylnitrosourea
Mice
Mice, Inbred BALB C
Pazos, P.
Lanari, C.
Elizalde, P.
Montecchia, F.
Charreau, E.H.
Molinolo, A.A.
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
topic_facet estrogen receptor
medroxyprogesterone acetate
methylnitrosourea
progesterone receptor
animal experiment
animal model
animal tissue
article
breast adenocarcinoma
breast carcinogenesis
breast tumor
cell differentiation
controlled study
female
mouse
nonhuman
priority journal
promoter region
Adenocarcinoma
Animals
Carcinogens
Cocarcinogenesis
Female
Mammary Neoplasms, Experimental
Medroxyprogesterone 17-Acetate
Methylnitrosourea
Mice
Mice, Inbred BALB C
description The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions.
format JOUR
author Pazos, P.
Lanari, C.
Elizalde, P.
Montecchia, F.
Charreau, E.H.
Molinolo, A.A.
author_facet Pazos, P.
Lanari, C.
Elizalde, P.
Montecchia, F.
Charreau, E.H.
Molinolo, A.A.
author_sort Pazos, P.
title Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
title_short Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
title_full Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
title_fullStr Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
title_full_unstemmed Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
title_sort promoter effect of medroxyprogesterone acetate (mpa) in n-methyl-n-nitrosourea (mnu) induced mammary tumors in balb/c mice
url http://hdl.handle.net/20.500.12110/paper_01433334_v19_n3_p529_Pazos
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