Endogenous galectin-3 controls experimental malaria in a species-specific manner

Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of hos...

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Detalles Bibliográficos
Autores principales:	Toscano, M.A., Tongren, J.E., De Souza, J.B., Liu, F.-T., Riley, E.M., Rabinovich, G.A.
Formato:	JOUR
Materias:	Galectin-3 Immunoglobulin G Plasmodium spp. galectin 3 immunoglobulin G2b protozoon antibody animal cell animal experiment animal model antibody response antibody titer article controlled study erythrocyte hematocrit host pathogen interaction immunoglobulin blood level lymphocyte monocyte mouse nonhuman parasitemia Plasmodium berghei Plasmodium berghei infection Plasmodium chabaudi Plasmodium chabaudi infection Plasmodium yoelii Plasmodium yoelii infection polymorphonuclear cell priority journal protein deficiency reticulocyte species difference wild type Animals Antibodies, Protozoan Disease Models, Animal Female Galectin 3 Host-Pathogen Interactions Malaria Mice Mice, Knockout Parasitemia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01419838_v34_n7_p383_Toscano
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_01419838_v34_n7_p383_Toscano2023-10-03T14:58:51Z Endogenous galectin-3 controls experimental malaria in a species-specific manner Toscano, M.A. Tongren, J.E. De Souza, J.B. Liu, F.-T. Riley, E.M. Rabinovich, G.A. Galectin-3 Immunoglobulin G Plasmodium spp. galectin 3 immunoglobulin G2b protozoon antibody animal cell animal experiment animal model antibody response antibody titer article controlled study erythrocyte hematocrit host pathogen interaction immunoglobulin blood level lymphocyte monocyte mouse nonhuman parasitemia Plasmodium berghei Plasmodium berghei infection Plasmodium chabaudi Plasmodium chabaudi infection Plasmodium yoelii Plasmodium yoelii infection polymorphonuclear cell priority journal protein deficiency reticulocyte species difference wild type Animals Antibodies, Protozoan Disease Models, Animal Female Galectin 3 Host-Pathogen Interactions Immunoglobulin G Malaria Mice Mice, Knockout Parasitemia Plasmodium berghei Plasmodium chabaudi Plasmodium yoelii Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host-pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3 -/- mice was consistent with higher titres of anti-P. yoelii MSP1 19 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses. © 2012 Blackwell Publishing Ltd. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01419838_v34_n7_p383_Toscano
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Galectin-3 Immunoglobulin G Plasmodium spp. galectin 3 immunoglobulin G2b protozoon antibody animal cell animal experiment animal model antibody response antibody titer article controlled study erythrocyte hematocrit host pathogen interaction immunoglobulin blood level lymphocyte monocyte mouse nonhuman parasitemia Plasmodium berghei Plasmodium berghei infection Plasmodium chabaudi Plasmodium chabaudi infection Plasmodium yoelii Plasmodium yoelii infection polymorphonuclear cell priority journal protein deficiency reticulocyte species difference wild type Animals Antibodies, Protozoan Disease Models, Animal Female Galectin 3 Host-Pathogen Interactions Immunoglobulin G Malaria Mice Mice, Knockout Parasitemia Plasmodium berghei Plasmodium chabaudi Plasmodium yoelii
spellingShingle	Galectin-3 Immunoglobulin G Plasmodium spp. galectin 3 immunoglobulin G2b protozoon antibody animal cell animal experiment animal model antibody response antibody titer article controlled study erythrocyte hematocrit host pathogen interaction immunoglobulin blood level lymphocyte monocyte mouse nonhuman parasitemia Plasmodium berghei Plasmodium berghei infection Plasmodium chabaudi Plasmodium chabaudi infection Plasmodium yoelii Plasmodium yoelii infection polymorphonuclear cell priority journal protein deficiency reticulocyte species difference wild type Animals Antibodies, Protozoan Disease Models, Animal Female Galectin 3 Host-Pathogen Interactions Immunoglobulin G Malaria Mice Mice, Knockout Parasitemia Plasmodium berghei Plasmodium chabaudi Plasmodium yoelii Toscano, M.A. Tongren, J.E. De Souza, J.B. Liu, F.-T. Riley, E.M. Rabinovich, G.A. Endogenous galectin-3 controls experimental malaria in a species-specific manner
topic_facet	Galectin-3 Immunoglobulin G Plasmodium spp. galectin 3 immunoglobulin G2b protozoon antibody animal cell animal experiment animal model antibody response antibody titer article controlled study erythrocyte hematocrit host pathogen interaction immunoglobulin blood level lymphocyte monocyte mouse nonhuman parasitemia Plasmodium berghei Plasmodium berghei infection Plasmodium chabaudi Plasmodium chabaudi infection Plasmodium yoelii Plasmodium yoelii infection polymorphonuclear cell priority journal protein deficiency reticulocyte species difference wild type Animals Antibodies, Protozoan Disease Models, Animal Female Galectin 3 Host-Pathogen Interactions Immunoglobulin G Malaria Mice Mice, Knockout Parasitemia Plasmodium berghei Plasmodium chabaudi Plasmodium yoelii
description	Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host-pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3 -/- mice was consistent with higher titres of anti-P. yoelii MSP1 19 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses. © 2012 Blackwell Publishing Ltd.
format	JOUR
author	Toscano, M.A. Tongren, J.E. De Souza, J.B. Liu, F.-T. Riley, E.M. Rabinovich, G.A.
author_facet	Toscano, M.A. Tongren, J.E. De Souza, J.B. Liu, F.-T. Riley, E.M. Rabinovich, G.A.
author_sort	Toscano, M.A.
title	Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_short	Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_full	Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_fullStr	Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_full_unstemmed	Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_sort	endogenous galectin-3 controls experimental malaria in a species-specific manner
url	http://hdl.handle.net/20.500.12110/paper_01419838_v34_n7_p383_Toscano
work_keys_str_mv	AT toscanoma endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner AT tongrenje endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner AT desouzajb endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner AT liuft endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner AT rileyem endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner AT rabinovichga endogenousgalectin3controlsexperimentalmalariainaspeciesspecificmanner
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Endogenous galectin-3 controls experimental malaria in a species-specific manner

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