In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides
Water-soluble sulfated polysaccharides from the red seaweed Nemalion helminthoides: two xylomannan fractions (N3 and N4) and a mannan fraction (N6) were investigated to determine their in vitro and in vivo immunomodulatory activities. N3 and N4 induced in vitro proliferation of macrophages of the mu...
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todo:paper_01418130_v63_n_p38_PerezRecalde2023-10-03T14:58:48Z In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides Pérez-Recalde, M. Matulewicz, M.C. Pujol, C.A. Carlucci, M.J. Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans immunomodulating agent interleukin 6 mannan mannan fraction nitric oxide polysaccharide sulfate sulfated mannan sulfated xylomannan tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model article cell proliferation concentration response controlled study cytokine production cytokine release cytotoxicity drug activity herpes simplex Herpes simplex virus 2 immunomodulation in vitro study in vivo study infection prevention macrophage male mouse nonhuman protein blood level red alga Human herpesvirus 2 Murinae Mus Nemalion helminthoides Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans Animals Cell Proliferation Immunomodulation Interleukin-6 Macrophages Mice Nitric Oxide Oligosaccharides Polysaccharides Seaweed Tumor Necrosis Factor-alpha Water-soluble sulfated polysaccharides from the red seaweed Nemalion helminthoides: two xylomannan fractions (N3 and N4) and a mannan fraction (N6) were investigated to determine their in vitro and in vivo immunomodulatory activities. N3 and N4 induced in vitro proliferation of macrophages of the murine cell line RAW 264.7 and significantly stimulated the production of nitric oxide (NO) and cytokines (IL-6 and TNF-α) in the same cells, whereas this response was not observed with the mannan N6. The cytokine production was also stimulated by sulfated xylomannans in vivo in BALB/c mice inoculated intravenously with these polysaccharides. Remarkably, when mice were treated with N3 and N4 for 1. h before being infected with Herpes simplex virus type 2, they remained asymptomatic with no signs of disease. The in vitro and in vivo results suggest that sulfated xylomannans could be strong immunomodulators. © 2013 Elsevier B.V. Fil:Pérez-Recalde, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carlucci, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01418130_v63_n_p38_PerezRecalde |
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Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans immunomodulating agent interleukin 6 mannan mannan fraction nitric oxide polysaccharide sulfate sulfated mannan sulfated xylomannan tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model article cell proliferation concentration response controlled study cytokine production cytokine release cytotoxicity drug activity herpes simplex Herpes simplex virus 2 immunomodulation in vitro study in vivo study infection prevention macrophage male mouse nonhuman protein blood level red alga Human herpesvirus 2 Murinae Mus Nemalion helminthoides Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans Animals Cell Proliferation Immunomodulation Interleukin-6 Macrophages Mice Nitric Oxide Oligosaccharides Polysaccharides Seaweed Tumor Necrosis Factor-alpha |
| spellingShingle |
Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans immunomodulating agent interleukin 6 mannan mannan fraction nitric oxide polysaccharide sulfate sulfated mannan sulfated xylomannan tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model article cell proliferation concentration response controlled study cytokine production cytokine release cytotoxicity drug activity herpes simplex Herpes simplex virus 2 immunomodulation in vitro study in vivo study infection prevention macrophage male mouse nonhuman protein blood level red alga Human herpesvirus 2 Murinae Mus Nemalion helminthoides Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans Animals Cell Proliferation Immunomodulation Interleukin-6 Macrophages Mice Nitric Oxide Oligosaccharides Polysaccharides Seaweed Tumor Necrosis Factor-alpha Pérez-Recalde, M. Matulewicz, M.C. Pujol, C.A. Carlucci, M.J. In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| topic_facet |
Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans immunomodulating agent interleukin 6 mannan mannan fraction nitric oxide polysaccharide sulfate sulfated mannan sulfated xylomannan tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model article cell proliferation concentration response controlled study cytokine production cytokine release cytotoxicity drug activity herpes simplex Herpes simplex virus 2 immunomodulation in vitro study in vivo study infection prevention macrophage male mouse nonhuman protein blood level red alga Human herpesvirus 2 Murinae Mus Nemalion helminthoides Immunomodulatory activity Nemalion helminthoides Sulfated xylomannans Animals Cell Proliferation Immunomodulation Interleukin-6 Macrophages Mice Nitric Oxide Oligosaccharides Polysaccharides Seaweed Tumor Necrosis Factor-alpha |
| description |
Water-soluble sulfated polysaccharides from the red seaweed Nemalion helminthoides: two xylomannan fractions (N3 and N4) and a mannan fraction (N6) were investigated to determine their in vitro and in vivo immunomodulatory activities. N3 and N4 induced in vitro proliferation of macrophages of the murine cell line RAW 264.7 and significantly stimulated the production of nitric oxide (NO) and cytokines (IL-6 and TNF-α) in the same cells, whereas this response was not observed with the mannan N6. The cytokine production was also stimulated by sulfated xylomannans in vivo in BALB/c mice inoculated intravenously with these polysaccharides. Remarkably, when mice were treated with N3 and N4 for 1. h before being infected with Herpes simplex virus type 2, they remained asymptomatic with no signs of disease. The in vitro and in vivo results suggest that sulfated xylomannans could be strong immunomodulators. © 2013 Elsevier B.V. |
| format |
JOUR |
| author |
Pérez-Recalde, M. Matulewicz, M.C. Pujol, C.A. Carlucci, M.J. |
| author_facet |
Pérez-Recalde, M. Matulewicz, M.C. Pujol, C.A. Carlucci, M.J. |
| author_sort |
Pérez-Recalde, M. |
| title |
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| title_short |
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| title_full |
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| title_fullStr |
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| title_full_unstemmed |
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides |
| title_sort |
in vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed nemalion helminthoides |
| url |
http://hdl.handle.net/20.500.12110/paper_01418130_v63_n_p38_PerezRecalde |
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