Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis
Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), α(1 → 4)-d-glucans and β(1 → 4)-d-mannans. The former polysaccharides are composed by 3-linked β-d-galactopyranose and β-l-arabinopyranose residues, they are highly su...
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todo:paper_01418130_v41_n5_p641_Ciancia2023-10-03T14:58:46Z Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis Ciancia, M. Quintana, I. Vizcargüénaga, M.I. Kasulin, L. de Dios, A. Estevez, J.M. Cerezo, A.S. Anticoagulant activity Platelet aggregation Sulfated arabinogalactans alpha 1,4 dextro glucan arabinogalactan arabinose beta 1,4 dextro mannan glucan mannan polysaccharide pyruvic acid unclassified drug anticoagulation article Codium fragile Codium vermilara hemostasis methylation nuclear magnetic resonance spectroscopy room temperature seaweed sulfation thrombocyte aggregation Anticoagulants Arabinose Galactose Hemostasis Humans Magnetic Resonance Spectroscopy Platelet Aggregation Polysaccharides Pronase Seaweed Codium fragile Codium vermilara Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), α(1 → 4)-d-glucans and β(1 → 4)-d-mannans. The former polysaccharides are composed by 3-linked β-d-galactopyranose and β-l-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content. © 2007 Elsevier B.V. All rights reserved. Fil:Ciancia, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de Dios, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Estevez, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerezo, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01418130_v41_n5_p641_Ciancia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anticoagulant activity Platelet aggregation Sulfated arabinogalactans alpha 1,4 dextro glucan arabinogalactan arabinose beta 1,4 dextro mannan glucan mannan polysaccharide pyruvic acid unclassified drug anticoagulation article Codium fragile Codium vermilara hemostasis methylation nuclear magnetic resonance spectroscopy room temperature seaweed sulfation thrombocyte aggregation Anticoagulants Arabinose Galactose Hemostasis Humans Magnetic Resonance Spectroscopy Platelet Aggregation Polysaccharides Pronase Seaweed Codium fragile Codium vermilara |
| spellingShingle |
Anticoagulant activity Platelet aggregation Sulfated arabinogalactans alpha 1,4 dextro glucan arabinogalactan arabinose beta 1,4 dextro mannan glucan mannan polysaccharide pyruvic acid unclassified drug anticoagulation article Codium fragile Codium vermilara hemostasis methylation nuclear magnetic resonance spectroscopy room temperature seaweed sulfation thrombocyte aggregation Anticoagulants Arabinose Galactose Hemostasis Humans Magnetic Resonance Spectroscopy Platelet Aggregation Polysaccharides Pronase Seaweed Codium fragile Codium vermilara Ciancia, M. Quintana, I. Vizcargüénaga, M.I. Kasulin, L. de Dios, A. Estevez, J.M. Cerezo, A.S. Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| topic_facet |
Anticoagulant activity Platelet aggregation Sulfated arabinogalactans alpha 1,4 dextro glucan arabinogalactan arabinose beta 1,4 dextro mannan glucan mannan polysaccharide pyruvic acid unclassified drug anticoagulation article Codium fragile Codium vermilara hemostasis methylation nuclear magnetic resonance spectroscopy room temperature seaweed sulfation thrombocyte aggregation Anticoagulants Arabinose Galactose Hemostasis Humans Magnetic Resonance Spectroscopy Platelet Aggregation Polysaccharides Pronase Seaweed Codium fragile Codium vermilara |
| description |
Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), α(1 → 4)-d-glucans and β(1 → 4)-d-mannans. The former polysaccharides are composed by 3-linked β-d-galactopyranose and β-l-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content. © 2007 Elsevier B.V. All rights reserved. |
| format |
JOUR |
| author |
Ciancia, M. Quintana, I. Vizcargüénaga, M.I. Kasulin, L. de Dios, A. Estevez, J.M. Cerezo, A.S. |
| author_facet |
Ciancia, M. Quintana, I. Vizcargüénaga, M.I. Kasulin, L. de Dios, A. Estevez, J.M. Cerezo, A.S. |
| author_sort |
Ciancia, M. |
| title |
Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| title_short |
Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| title_full |
Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| title_fullStr |
Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| title_full_unstemmed |
Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis |
| title_sort |
polysaccharides from the green seaweeds codium fragile and c. vermilara with controversial effects on hemostasis |
| url |
http://hdl.handle.net/20.500.12110/paper_01418130_v41_n5_p641_Ciancia |
| work_keys_str_mv |
AT cianciam polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT quintanai polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT vizcarguenagami polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT kasulinl polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT dediosa polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT estevezjm polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis AT cerezoas polysaccharidesfromthegreenseaweedscodiumfragileandcvermilarawithcontroversialeffectsonhemostasis |
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1807323468475138048 |