Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition
Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loo...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00928674_v160_n6_p1182_Doncic |
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todo:paper_00928674_v160_n6_p1182_Doncic2023-10-03T14:55:22Z Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition Doncic, A. Atay, O. Valk, E. Grande, A. Bush, A. Vasen, G. Colman-Lerner, A. Loog, M. Skotheim, J.M. pheromone CDC24 protein, S cerevisiae cell cycle protein CLN2 protein, S cerevisiae cyclin dependent kinase inhibitor cycline FAR1 protein, S cerevisiae guanine nucleotide exchange factor pheromone Saccharomyces cerevisiae protein Article cell compartmentalization cell cycle G1 phase cell cycle S phase cytoplasm feedback system molecular dynamics nonhuman priority journal protein binding signal transduction cytology feedback system metabolism physiology Saccharomyces cerevisiae Eukaryota Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclins Cytoplasm Feedback, Physiological Guanine Nucleotide Exchange Factors Pheromones Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions. © 2015 Elsevier Inc. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00928674_v160_n6_p1182_Doncic |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
pheromone CDC24 protein, S cerevisiae cell cycle protein CLN2 protein, S cerevisiae cyclin dependent kinase inhibitor cycline FAR1 protein, S cerevisiae guanine nucleotide exchange factor pheromone Saccharomyces cerevisiae protein Article cell compartmentalization cell cycle G1 phase cell cycle S phase cytoplasm feedback system molecular dynamics nonhuman priority journal protein binding signal transduction cytology feedback system metabolism physiology Saccharomyces cerevisiae Eukaryota Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclins Cytoplasm Feedback, Physiological Guanine Nucleotide Exchange Factors Pheromones Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction |
| spellingShingle |
pheromone CDC24 protein, S cerevisiae cell cycle protein CLN2 protein, S cerevisiae cyclin dependent kinase inhibitor cycline FAR1 protein, S cerevisiae guanine nucleotide exchange factor pheromone Saccharomyces cerevisiae protein Article cell compartmentalization cell cycle G1 phase cell cycle S phase cytoplasm feedback system molecular dynamics nonhuman priority journal protein binding signal transduction cytology feedback system metabolism physiology Saccharomyces cerevisiae Eukaryota Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclins Cytoplasm Feedback, Physiological Guanine Nucleotide Exchange Factors Pheromones Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction Doncic, A. Atay, O. Valk, E. Grande, A. Bush, A. Vasen, G. Colman-Lerner, A. Loog, M. Skotheim, J.M. Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| topic_facet |
pheromone CDC24 protein, S cerevisiae cell cycle protein CLN2 protein, S cerevisiae cyclin dependent kinase inhibitor cycline FAR1 protein, S cerevisiae guanine nucleotide exchange factor pheromone Saccharomyces cerevisiae protein Article cell compartmentalization cell cycle G1 phase cell cycle S phase cytoplasm feedback system molecular dynamics nonhuman priority journal protein binding signal transduction cytology feedback system metabolism physiology Saccharomyces cerevisiae Eukaryota Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclins Cytoplasm Feedback, Physiological Guanine Nucleotide Exchange Factors Pheromones Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction |
| description |
Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions. © 2015 Elsevier Inc. |
| format |
JOUR |
| author |
Doncic, A. Atay, O. Valk, E. Grande, A. Bush, A. Vasen, G. Colman-Lerner, A. Loog, M. Skotheim, J.M. |
| author_facet |
Doncic, A. Atay, O. Valk, E. Grande, A. Bush, A. Vasen, G. Colman-Lerner, A. Loog, M. Skotheim, J.M. |
| author_sort |
Doncic, A. |
| title |
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| title_short |
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| title_full |
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| title_fullStr |
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| title_full_unstemmed |
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| title_sort |
compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| url |
http://hdl.handle.net/20.500.12110/paper_00928674_v160_n6_p1182_Doncic |
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1807324235798937600 |