Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus

The synthetic opioid analog [d-Ala2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab Chasmagnathus granulatus when administered within the dose range 0.01-1.0 μg/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-respo...

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Detalles Bibliográficos
Autores principales:	Godoy, A.M., Maldonado, H.
Formato:	JOUR
Materias:	Crab Habituation Met-enkephalin Opioid metenkephalin[2 dextro alanine] naloxone opiate animal experiment article controlled study crab dose response drug antagonism escape behavior habituation male nonhuman priority journal Animal Brachyura Enkephalin, Methionine Escape Reaction Male Pilot Projects
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00913057_v50_n3_p445_Godoy
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00913057_v50_n3_p445_Godoy
record_format	dspace
spelling	todo:paper_00913057_v50_n3_p445_Godoy2023-10-03T14:54:55Z Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus Godoy, A.M. Maldonado, H. Crab Habituation Met-enkephalin Opioid metenkephalin[2 dextro alanine] naloxone opiate animal experiment article controlled study crab dose response drug antagonism escape behavior habituation male nonhuman priority journal Animal Brachyura Enkephalin, Methionine Escape Reaction Male Pilot Projects The synthetic opioid analog [d-Ala2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab Chasmagnathus granulatus when administered within the dose range 0.01-1.0 μg/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-response curve. A 0.1-μg/g dose of naloxone has no effect per se on the response, but when it is administered together with DAME, it completely blocks the decrementai effect of this drug and an escape response generally higher than that of control is observed. An explanation for these results in terms of a possible dual action of DAME is offered. In addition, we present evidence for different degrees of opiate sensitivity among crabs of the same population in relation to their different degrees of reactivity to the visual danger stimulus. © 1995. Fil:Godoy, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00913057_v50_n3_p445_Godoy
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Crab Habituation Met-enkephalin Opioid metenkephalin[2 dextro alanine] naloxone opiate animal experiment article controlled study crab dose response drug antagonism escape behavior habituation male nonhuman priority journal Animal Brachyura Enkephalin, Methionine Escape Reaction Male Pilot Projects
spellingShingle	Crab Habituation Met-enkephalin Opioid metenkephalin[2 dextro alanine] naloxone opiate animal experiment article controlled study crab dose response drug antagonism escape behavior habituation male nonhuman priority journal Animal Brachyura Enkephalin, Methionine Escape Reaction Male Pilot Projects Godoy, A.M. Maldonado, H. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
topic_facet	Crab Habituation Met-enkephalin Opioid metenkephalin[2 dextro alanine] naloxone opiate animal experiment article controlled study crab dose response drug antagonism escape behavior habituation male nonhuman priority journal Animal Brachyura Enkephalin, Methionine Escape Reaction Male Pilot Projects
description	The synthetic opioid analog [d-Ala2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab Chasmagnathus granulatus when administered within the dose range 0.01-1.0 μg/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-response curve. A 0.1-μg/g dose of naloxone has no effect per se on the response, but when it is administered together with DAME, it completely blocks the decrementai effect of this drug and an escape response generally higher than that of control is observed. An explanation for these results in terms of a possible dual action of DAME is offered. In addition, we present evidence for different degrees of opiate sensitivity among crabs of the same population in relation to their different degrees of reactivity to the visual danger stimulus. © 1995.
format	JOUR
author	Godoy, A.M. Maldonado, H.
author_facet	Godoy, A.M. Maldonado, H.
author_sort	Godoy, A.M.
title	Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
title_short	Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
title_full	Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
title_fullStr	Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
title_full_unstemmed	Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
title_sort	modulation of the escape response by [d-ala2]met-enkephalin in the crab chasmagnathus
url	http://hdl.handle.net/20.500.12110/paper_00913057_v50_n3_p445_Godoy
work_keys_str_mv	AT godoyam modulationoftheescaperesponsebydala2metenkephalininthecrabchasmagnathus AT maldonadoh modulationoftheescaperesponsebydala2metenkephalininthecrabchasmagnathus
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Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus

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