The circling training rat model as a behavioral teratology test

The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and perfo...

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Autores principales:	Brusés, J.L., Berninsone, P.M., Ojea, S.I., Azcurra, J.M.
Formato:	JOUR
Materias:	Behavioral teratology Caudate nuclei Circling training Haloperidol Operant conditioning Vitamin A haloperidol retinol adolescent animal experiment animal model article behavior teratology circling behavior controlled study female instrumental conditioning intraperitoneal drug administration male mathematical analysis maze test nonhuman prenatal drug exposure priority journal rat training Animal Behavior, Animal Caudate Nucleus Conditioning, Operant Female Maternal-Fetal Exchange Pregnancy Rats Rats, Inbred Strains Support, Non-U.S. Gov't Teratogens
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00913057_v38_n4_p739_Bruses
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00913057_v38_n4_p739_Bruses
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spelling	todo:paper_00913057_v38_n4_p739_Bruses2023-10-03T14:54:54Z The circling training rat model as a behavioral teratology test Brusés, J.L. Berninsone, P.M. Ojea, S.I. Azcurra, J.M. Behavioral teratology Caudate nuclei Circling training Haloperidol Operant conditioning Vitamin A haloperidol retinol adolescent animal experiment animal model article behavior teratology circling behavior controlled study female instrumental conditioning intraperitoneal drug administration male mathematical analysis maze test nonhuman prenatal drug exposure priority journal rat training Animal Behavior, Animal Caudate Nucleus Conditioning, Operant Female Haloperidol Maternal-Fetal Exchange Pregnancy Rats Rats, Inbred Strains Support, Non-U.S. Gov't Teratogens Vitamin A The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and performed for 8 days in an automated apparatus. Statistically significant differences between drug-treated and control animals regarding the measured response (turns per minute) were found. Two components may affect the response measured by the CT: associative learning and motor performance. The incidence of these components was discriminated with behavioral and mathematical approaches. In the experimental conditions used the most affected parameter was motor performance. The results indicate that CT can be used as an instrumental conditioning test where the quantifiable endpoint is the on-going motor performance. Further applications of the CT for neurochemical evaluation of drug induced effects are also discussed. © 1991. Fil:Berninsone, P.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00913057_v38_n4_p739_Bruses
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Behavioral teratology Caudate nuclei Circling training Haloperidol Operant conditioning Vitamin A haloperidol retinol adolescent animal experiment animal model article behavior teratology circling behavior controlled study female instrumental conditioning intraperitoneal drug administration male mathematical analysis maze test nonhuman prenatal drug exposure priority journal rat training Animal Behavior, Animal Caudate Nucleus Conditioning, Operant Female Haloperidol Maternal-Fetal Exchange Pregnancy Rats Rats, Inbred Strains Support, Non-U.S. Gov't Teratogens Vitamin A
spellingShingle	Behavioral teratology Caudate nuclei Circling training Haloperidol Operant conditioning Vitamin A haloperidol retinol adolescent animal experiment animal model article behavior teratology circling behavior controlled study female instrumental conditioning intraperitoneal drug administration male mathematical analysis maze test nonhuman prenatal drug exposure priority journal rat training Animal Behavior, Animal Caudate Nucleus Conditioning, Operant Female Haloperidol Maternal-Fetal Exchange Pregnancy Rats Rats, Inbred Strains Support, Non-U.S. Gov't Teratogens Vitamin A Brusés, J.L. Berninsone, P.M. Ojea, S.I. Azcurra, J.M. The circling training rat model as a behavioral teratology test
topic_facet	Behavioral teratology Caudate nuclei Circling training Haloperidol Operant conditioning Vitamin A haloperidol retinol adolescent animal experiment animal model article behavior teratology circling behavior controlled study female instrumental conditioning intraperitoneal drug administration male mathematical analysis maze test nonhuman prenatal drug exposure priority journal rat training Animal Behavior, Animal Caudate Nucleus Conditioning, Operant Female Haloperidol Maternal-Fetal Exchange Pregnancy Rats Rats, Inbred Strains Support, Non-U.S. Gov't Teratogens Vitamin A
description	The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and performed for 8 days in an automated apparatus. Statistically significant differences between drug-treated and control animals regarding the measured response (turns per minute) were found. Two components may affect the response measured by the CT: associative learning and motor performance. The incidence of these components was discriminated with behavioral and mathematical approaches. In the experimental conditions used the most affected parameter was motor performance. The results indicate that CT can be used as an instrumental conditioning test where the quantifiable endpoint is the on-going motor performance. Further applications of the CT for neurochemical evaluation of drug induced effects are also discussed. © 1991.
format	JOUR
author	Brusés, J.L. Berninsone, P.M. Ojea, S.I. Azcurra, J.M.
author_facet	Brusés, J.L. Berninsone, P.M. Ojea, S.I. Azcurra, J.M.
author_sort	Brusés, J.L.
title	The circling training rat model as a behavioral teratology test
title_short	The circling training rat model as a behavioral teratology test
title_full	The circling training rat model as a behavioral teratology test
title_fullStr	The circling training rat model as a behavioral teratology test
title_full_unstemmed	The circling training rat model as a behavioral teratology test
title_sort	circling training rat model as a behavioral teratology test
url	http://hdl.handle.net/20.500.12110/paper_00913057_v38_n4_p739_Bruses
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_version_	1782026691221127168

The circling training rat model as a behavioral teratology test

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