Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus
Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Dos...
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| Autores principales: | , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00913057_v36_n4_p787_Tomsic |
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| Sumario: | Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Doses of morphine with maximal detrimental effect on the escape response (75-100 μg/g) showed no effect on the optokinetic response, both by measuring the crab's eyestalk displacement and by recording its body rotation, supporting the hypothesis of a morphine central action on the danger-induced escape re sponse. As regards the effet on habituation, a 75 μ morphine/g injection administered 30 min before the first trial produced a parallel shift of the short-term (within-session) habituation curve, suggesting a modulatory central drug action that would mimic a putative endogeneous opioid action. A 100 morphine μg/g dose injected 30 min before training sharply reduced reactivity during training and impaired the acquisition of long-term (between-session) habituation. It may be speculated that the decrease in the danger meaning of the stimulus due to morphine explains both effects in terms of a stimulation impairment during training. © 1990. |
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