Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus
Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Dos...
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todo:paper_00913057_v36_n4_p787_Tomsic2023-10-03T14:54:54Z Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus Tomsic, D. Maldonado, H. Danger stimulus Crustacea Long-term habituation Morphine Opiates Optokinetic response Short-term habituation morphine animal experiment article drug tolerance invertebrate nonhuman optokinetic stimulation priority journal Animal Brachyura Habituation (Psychophysiology) Male Morphine Motor Activity Support, Non-U.S. Gov't Animalia Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Doses of morphine with maximal detrimental effect on the escape response (75-100 μg/g) showed no effect on the optokinetic response, both by measuring the crab's eyestalk displacement and by recording its body rotation, supporting the hypothesis of a morphine central action on the danger-induced escape re sponse. As regards the effet on habituation, a 75 μ morphine/g injection administered 30 min before the first trial produced a parallel shift of the short-term (within-session) habituation curve, suggesting a modulatory central drug action that would mimic a putative endogeneous opioid action. A 100 morphine μg/g dose injected 30 min before training sharply reduced reactivity during training and impaired the acquisition of long-term (between-session) habituation. It may be speculated that the decrease in the danger meaning of the stimulus due to morphine explains both effects in terms of a stimulation impairment during training. © 1990. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00913057_v36_n4_p787_Tomsic |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Danger stimulus Crustacea Long-term habituation Morphine Opiates Optokinetic response Short-term habituation morphine animal experiment article drug tolerance invertebrate nonhuman optokinetic stimulation priority journal Animal Brachyura Habituation (Psychophysiology) Male Morphine Motor Activity Support, Non-U.S. Gov't Animalia Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata |
| spellingShingle |
Danger stimulus Crustacea Long-term habituation Morphine Opiates Optokinetic response Short-term habituation morphine animal experiment article drug tolerance invertebrate nonhuman optokinetic stimulation priority journal Animal Brachyura Habituation (Psychophysiology) Male Morphine Motor Activity Support, Non-U.S. Gov't Animalia Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Tomsic, D. Maldonado, H. Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| topic_facet |
Danger stimulus Crustacea Long-term habituation Morphine Opiates Optokinetic response Short-term habituation morphine animal experiment article drug tolerance invertebrate nonhuman optokinetic stimulation priority journal Animal Brachyura Habituation (Psychophysiology) Male Morphine Motor Activity Support, Non-U.S. Gov't Animalia Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata |
| description |
Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Doses of morphine with maximal detrimental effect on the escape response (75-100 μg/g) showed no effect on the optokinetic response, both by measuring the crab's eyestalk displacement and by recording its body rotation, supporting the hypothesis of a morphine central action on the danger-induced escape re sponse. As regards the effet on habituation, a 75 μ morphine/g injection administered 30 min before the first trial produced a parallel shift of the short-term (within-session) habituation curve, suggesting a modulatory central drug action that would mimic a putative endogeneous opioid action. A 100 morphine μg/g dose injected 30 min before training sharply reduced reactivity during training and impaired the acquisition of long-term (between-session) habituation. It may be speculated that the decrease in the danger meaning of the stimulus due to morphine explains both effects in terms of a stimulation impairment during training. © 1990. |
| format |
JOUR |
| author |
Tomsic, D. Maldonado, H. |
| author_facet |
Tomsic, D. Maldonado, H. |
| author_sort |
Tomsic, D. |
| title |
Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_short |
Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_full |
Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_fullStr |
Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_full_unstemmed |
Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_sort |
central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab chasmagnathus |
| url |
http://hdl.handle.net/20.500.12110/paper_00913057_v36_n4_p787_Tomsic |
| work_keys_str_mv |
AT tomsicd centraleffectofmorphinepretreatmentonshortandlongtermhabituationtoadangerstimulusinthecrabchasmagnathus AT maldonadoh centraleffectofmorphinepretreatmentonshortandlongtermhabituationtoadangerstimulusinthecrabchasmagnathus |
| _version_ |
1807320255122374656 |