Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism

Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its...

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Autores principales: Chazenbalk, G.D., Valsecchi, R.M., Krwaiec, L., Burton, G., Juvenal, G.J., Monteagudo, E., Chester, H.A., Pisarev, M.A.
Formato: JOUR
Materias:
15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
arachidonic acid derivative
liothyronine
radioisotope
thyroid iodine
unclassified drug
animal cell
animal experiment
article
autoregulation
cattle
controlled study
intraperitoneal drug administration
newborn
nonhuman
rat
thyroid gland
Animalia
Bos taurus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v36_n2_p163_Chazenbalk
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v36_n2_p163_Chazenbalk
record_format dspace
spelling todo:paper_00906980_v36_n2_p163_Chazenbalk2023-10-03T14:54:51Z Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism Chazenbalk, G.D. Valsecchi, R.M. Krwaiec, L. Burton, G. Juvenal, G.J. Monteagudo, E. Chester, H.A. Pisarev, M.A. 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid arachidonic acid derivative liothyronine radioisotope thyroid iodine unclassified drug animal cell animal experiment article autoregulation cattle controlled study intraperitoneal drug administration newborn nonhuman rat thyroid gland Animalia Bos taurus Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its omega lactone (IL-ω);3)5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid delta lactone (IL-δ). Their action on iodine metabolism was studied. Iodine uptake was measured in calf thyroid slices. At 10-4M I-OH-A caused a 64% decrease in the T/M ratio while IL-ω inhibited it by 36% and IL-δ was without effect. At 10−5M the inhibition was 44% for I-OH-A and 19% for IL-ω, while T3 was without action. A possible isotopic dilution effect was excluded, and no change in iodine efflux was observed. The inhibition by I-OH-A of iodine uptake was observed after only 15 min preincubation. This compound alse decreased 125I accumulation in rats. In calf thyroid slice, I-OH-A at 10−4M, inhibited PB125I formation by 80%, IL-ω 62% and IL-ω by 37% and arachidonic acid were without action. I-OH-A also caused a dose-dependent inhibition of TSH-stimulated iodide organification. The present results demonstrate, for the first time, that iodinated derivatives of arachidonic acid inhibition thyroid function and mimic the effect of iodine on thyroid autoregulation. © 1988, All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v36_n2_p163_Chazenbalk
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
arachidonic acid derivative
liothyronine
radioisotope
thyroid iodine
unclassified drug
animal cell
animal experiment
article
autoregulation
cattle
controlled study
intraperitoneal drug administration
newborn
nonhuman
rat
thyroid gland
Animalia
Bos taurus
spellingShingle 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
arachidonic acid derivative
liothyronine
radioisotope
thyroid iodine
unclassified drug
animal cell
animal experiment
article
autoregulation
cattle
controlled study
intraperitoneal drug administration
newborn
nonhuman
rat
thyroid gland
Animalia
Bos taurus
Chazenbalk, G.D.
Valsecchi, R.M.
Krwaiec, L.
Burton, G.
Juvenal, G.J.
Monteagudo, E.
Chester, H.A.
Pisarev, M.A.
Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
topic_facet 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
15 hydroxy 14 iodo 5,8,11 icosatrienoic acid
arachidonic acid derivative
liothyronine
radioisotope
thyroid iodine
unclassified drug
animal cell
animal experiment
article
autoregulation
cattle
controlled study
intraperitoneal drug administration
newborn
nonhuman
rat
thyroid gland
Animalia
Bos taurus
description Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its omega lactone (IL-ω);3)5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid delta lactone (IL-δ). Their action on iodine metabolism was studied. Iodine uptake was measured in calf thyroid slices. At 10-4M I-OH-A caused a 64% decrease in the T/M ratio while IL-ω inhibited it by 36% and IL-δ was without effect. At 10−5M the inhibition was 44% for I-OH-A and 19% for IL-ω, while T3 was without action. A possible isotopic dilution effect was excluded, and no change in iodine efflux was observed. The inhibition by I-OH-A of iodine uptake was observed after only 15 min preincubation. This compound alse decreased 125I accumulation in rats. In calf thyroid slice, I-OH-A at 10−4M, inhibited PB125I formation by 80%, IL-ω 62% and IL-ω by 37% and arachidonic acid were without action. I-OH-A also caused a dose-dependent inhibition of TSH-stimulated iodide organification. The present results demonstrate, for the first time, that iodinated derivatives of arachidonic acid inhibition thyroid function and mimic the effect of iodine on thyroid autoregulation. © 1988, All rights reserved.
format JOUR
author Chazenbalk, G.D.
Valsecchi, R.M.
Krwaiec, L.
Burton, G.
Juvenal, G.J.
Monteagudo, E.
Chester, H.A.
Pisarev, M.A.
author_facet Chazenbalk, G.D.
Valsecchi, R.M.
Krwaiec, L.
Burton, G.
Juvenal, G.J.
Monteagudo, E.
Chester, H.A.
Pisarev, M.A.
author_sort Chazenbalk, G.D.
title Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
title_short Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
title_full Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
title_fullStr Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
title_full_unstemmed Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
title_sort thyroid autoregulation. inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
url http://hdl.handle.net/20.500.12110/paper_00906980_v36_n2_p163_Chazenbalk
work_keys_str_mv AT chazenbalkgd thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT valsecchirm thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT krwaiecl thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT burtong thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT juvenalgj thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT monteagudoe thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT chesterha thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
AT pisarevma thyroidautoregulationinhibitoryeffectsofiodinatedderivativesofarachidonicacidoniodinemetabolism
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