Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries

Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was document...

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Autores principales: Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A., Gimeno, A.L.
Formato: JOUR
Materias:
6 oxoprostaglandin e1
6 oxoprostaglandin f1 alpha
prostacyclin
animal experiment
blood and hemopoietic system
cattle
coronary artery
coronary artery obstruction
drug metabolism
heart
heart muscle ischemia
in vitro study
peripheral vascular system
plasma
smooth muscle contractility
thrombocyte
thrombocyte aggregation
thrombosis
vasoconstriction
6-Ketoprostaglandin F1 alpha
Adenosine Diphosphate
Animals
Anticoagulants
Blood Platelets
Blood Proteins
Cattle
Coronary Vessels
Epoprostenol
Humans
Muscle Contraction
Muscle, Smooth, Vascular
Platelet Aggregation
Prostaglandins
Prostaglandins F
Prostaglandins, Synthetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v19_n6_p907_Gimeno
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v19_n6_p907_Gimeno
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spelling todo:paper_00906980_v19_n6_p907_Gimeno2023-10-03T14:54:45Z Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries Gimeno, M.F. Sterin-Borda, L. Borda, E.S. Lazzari, M.A. Gimeno, A.L. 6 oxoprostaglandin e1 6 oxoprostaglandin f1 alpha prostacyclin animal experiment blood and hemopoietic system cattle coronary artery coronary artery obstruction drug metabolism heart heart muscle ischemia in vitro study peripheral vascular system plasma smooth muscle contractility thrombocyte thrombocyte aggregation thrombosis vasoconstriction 6-Ketoprostaglandin F1 alpha Adenosine Diphosphate Animals Anticoagulants Blood Platelets Blood Proteins Cattle Coronary Vessels Epoprostenol Humans Muscle Contraction Muscle, Smooth, Vascular Platelet Aggregation Prostaglandins Prostaglandins F Prostaglandins, Synthetic Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was documented that incubates in PRP or in PPP retain an antiaggregatory activity at higher levels and during a longer time than in KRB. On the other hand, PGI2 incubates in KRB exhibited only a relaxing activity on isolated bovine coronary arteries, whereas when incubated in PRP or in PPP presented a biphasic influence. The initial effects (evoked by incubates of 30 minutes) were distinctly relaxing but those obtained with later incubates (60-150 minutes) stimulated clearly the resting basal tone of the arteries. The possibility that the human plasma might have an enzyme(s) able to transform prostacyclin into a more stable material with human antiaggregatory platelet function and bovine coronary contracting capacity is discussed. © 1980. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v19_n6_p907_Gimeno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 6 oxoprostaglandin e1
6 oxoprostaglandin f1 alpha
prostacyclin
animal experiment
blood and hemopoietic system
cattle
coronary artery
coronary artery obstruction
drug metabolism
heart
heart muscle ischemia
in vitro study
peripheral vascular system
plasma
smooth muscle contractility
thrombocyte
thrombocyte aggregation
thrombosis
vasoconstriction
6-Ketoprostaglandin F1 alpha
Adenosine Diphosphate
Animals
Anticoagulants
Blood Platelets
Blood Proteins
Cattle
Coronary Vessels
Epoprostenol
Humans
Muscle Contraction
Muscle, Smooth, Vascular
Platelet Aggregation
Prostaglandins
Prostaglandins F
Prostaglandins, Synthetic
spellingShingle 6 oxoprostaglandin e1
6 oxoprostaglandin f1 alpha
prostacyclin
animal experiment
blood and hemopoietic system
cattle
coronary artery
coronary artery obstruction
drug metabolism
heart
heart muscle ischemia
in vitro study
peripheral vascular system
plasma
smooth muscle contractility
thrombocyte
thrombocyte aggregation
thrombosis
vasoconstriction
6-Ketoprostaglandin F1 alpha
Adenosine Diphosphate
Animals
Anticoagulants
Blood Platelets
Blood Proteins
Cattle
Coronary Vessels
Epoprostenol
Humans
Muscle Contraction
Muscle, Smooth, Vascular
Platelet Aggregation
Prostaglandins
Prostaglandins F
Prostaglandins, Synthetic
Gimeno, M.F.
Sterin-Borda, L.
Borda, E.S.
Lazzari, M.A.
Gimeno, A.L.
Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
topic_facet 6 oxoprostaglandin e1
6 oxoprostaglandin f1 alpha
prostacyclin
animal experiment
blood and hemopoietic system
cattle
coronary artery
coronary artery obstruction
drug metabolism
heart
heart muscle ischemia
in vitro study
peripheral vascular system
plasma
smooth muscle contractility
thrombocyte
thrombocyte aggregation
thrombosis
vasoconstriction
6-Ketoprostaglandin F1 alpha
Adenosine Diphosphate
Animals
Anticoagulants
Blood Platelets
Blood Proteins
Cattle
Coronary Vessels
Epoprostenol
Humans
Muscle Contraction
Muscle, Smooth, Vascular
Platelet Aggregation
Prostaglandins
Prostaglandins F
Prostaglandins, Synthetic
description Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was documented that incubates in PRP or in PPP retain an antiaggregatory activity at higher levels and during a longer time than in KRB. On the other hand, PGI2 incubates in KRB exhibited only a relaxing activity on isolated bovine coronary arteries, whereas when incubated in PRP or in PPP presented a biphasic influence. The initial effects (evoked by incubates of 30 minutes) were distinctly relaxing but those obtained with later incubates (60-150 minutes) stimulated clearly the resting basal tone of the arteries. The possibility that the human plasma might have an enzyme(s) able to transform prostacyclin into a more stable material with human antiaggregatory platelet function and bovine coronary contracting capacity is discussed. © 1980.
format JOUR
author Gimeno, M.F.
Sterin-Borda, L.
Borda, E.S.
Lazzari, M.A.
Gimeno, A.L.
author_facet Gimeno, M.F.
Sterin-Borda, L.
Borda, E.S.
Lazzari, M.A.
Gimeno, A.L.
author_sort Gimeno, M.F.
title Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
title_short Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
title_full Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
title_fullStr Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
title_full_unstemmed Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
title_sort human plasma transforms prostacyclin (pgi2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
url http://hdl.handle.net/20.500.12110/paper_00906980_v19_n6_p907_Gimeno
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AT bordaes humanplasmatransformsprostacyclinpgi2intoaplateletantiaggregatorysubstancewhichcontractsisolatedbovinecoronaryarteries
AT lazzarima humanplasmatransformsprostacyclinpgi2intoaplateletantiaggregatorysubstancewhichcontractsisolatedbovinecoronaryarteries
AT gimenoal humanplasmatransformsprostacyclinpgi2intoaplateletantiaggregatorysubstancewhichcontractsisolatedbovinecoronaryarteries
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