Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?

Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (ab...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gimeno, M.F., Sterin-Speziale, N., Landa, A., Bonacossa, A., Gimeno, A.L.
Formato: JOUR
Materias:
indometacin
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal experiment
estrus
female genital system
in vitro study
metestrus
rat
uterus contraction
Animals
Estrus
Female
Indomethacin
Ovary
Pregnancy
Prostaglandins E
Prostaglandins F
Rats
Secretory Rate
Time Factors
Uterine Contraction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v17_n5_p673_Gimeno
record_format dspace
spelling todo:paper_00906980_v17_n5_p673_Gimeno2023-10-03T14:54:44Z Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? Gimeno, M.F. Sterin-Speziale, N. Landa, A. Bonacossa, A. Gimeno, A.L. indometacin prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal experiment estrus female genital system in vitro study metestrus rat uterus contraction Animals Estrus Female Indomethacin Ovary Pregnancy Prostaglandins E Prostaglandins F Rats Secretory Rate Time Factors Uterine Contraction Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF. © 1979. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic indometacin
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal experiment
estrus
female genital system
in vitro study
metestrus
rat
uterus contraction
Animals
Estrus
Female
Indomethacin
Ovary
Pregnancy
Prostaglandins E
Prostaglandins F
Rats
Secretory Rate
Time Factors
Uterine Contraction
spellingShingle indometacin
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal experiment
estrus
female genital system
in vitro study
metestrus
rat
uterus contraction
Animals
Estrus
Female
Indomethacin
Ovary
Pregnancy
Prostaglandins E
Prostaglandins F
Rats
Secretory Rate
Time Factors
Uterine Contraction
Gimeno, M.F.
Sterin-Speziale, N.
Landa, A.
Bonacossa, A.
Gimeno, A.L.
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
topic_facet indometacin
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal experiment
estrus
female genital system
in vitro study
metestrus
rat
uterus contraction
Animals
Estrus
Female
Indomethacin
Ovary
Pregnancy
Prostaglandins E
Prostaglandins F
Rats
Secretory Rate
Time Factors
Uterine Contraction
description Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF. © 1979.
format JOUR
author Gimeno, M.F.
Sterin-Speziale, N.
Landa, A.
Bonacossa, A.
Gimeno, A.L.
author_facet Gimeno, M.F.
Sterin-Speziale, N.
Landa, A.
Bonacossa, A.
Gimeno, A.L.
author_sort Gimeno, M.F.
title Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
title_short Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
title_full Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
title_fullStr Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
title_full_unstemmed Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
title_sort is the spontaneous motility of isolated rat uterus controlled by prostaglandin e?
url http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno
work_keys_str_mv AT gimenomf isthespontaneousmotilityofisolatedratuteruscontrolledbyprostaglandine
AT sterinspezialen isthespontaneousmotilityofisolatedratuteruscontrolledbyprostaglandine
AT landaa isthespontaneousmotilityofisolatedratuteruscontrolledbyprostaglandine
AT bonacossaa isthespontaneousmotilityofisolatedratuteruscontrolledbyprostaglandine
AT gimenoal isthespontaneousmotilityofisolatedratuteruscontrolledbyprostaglandine
_version_ 1807324293581766656

Ejemplares similares