Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction

Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunologica...

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Autores principales:	Nudler, S., Piriz, J., Urbano, F.J., Rosato-Siri, M.D., Piedras Renteria, E.S., Uchitel, O.D.
Formato:	SER
Materias:	Calcium channels Calcium dependence Miniature endplate potentials Neuromuscular junction Transmitter release calcium channel calcium channel blocking agent calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type immunoglobulin neurotransmitter nitrendipine okadaic acid omega agatoxin omega agatoxin gvia omega agatoxin IVA snx 482 unclassified drug agents interacting with transmitter, hormone or drug receptors potassium ataxia chemical structure conference paper drug effect dystonia Eaton Lambert syndrome electric potential electrophysiology endplate potential exocytosis experiment genetic analysis genetic code human immune system knockout mouse nerve ending nerve potential neuromuscular synapse neurotransmitter release nonhuman pathophysiology structure analysis synaptic transmission adult aging animal classification fetus genetics metabolism mouse neuromuscular junction disorder newborn physiology rat review secretion synaptic membrane Ataxia Adult Aging Animals Animals, Newborn Calcium Channels, L-Type Calcium Channels, N-Type Fetus Humans Mice Neuromuscular Junction Neuromuscular Junction Diseases Neurotransmitter Agents Potassium Rats Synaptic Membranes Synaptic Transmission
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00778923_v998_n_p11_Nudler
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00778923_v998_n_p11_Nudler
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spelling	todo:paper_00778923_v998_n_p11_Nudler2023-10-03T14:54:25Z Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction Nudler, S. Piriz, J. Urbano, F.J. Rosato-Siri, M.D. Piedras Renteria, E.S. Uchitel, O.D. Calcium channels Calcium dependence Miniature endplate potentials Neuromuscular junction Transmitter release calcium channel calcium channel blocking agent calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type immunoglobulin neurotransmitter nitrendipine okadaic acid omega agatoxin omega agatoxin gvia omega agatoxin IVA snx 482 unclassified drug agents interacting with transmitter, hormone or drug receptors calcium channel N type potassium ataxia chemical structure conference paper drug effect dystonia Eaton Lambert syndrome electric potential electrophysiology endplate potential exocytosis experiment genetic analysis genetic code human immune system knockout mouse nerve ending nerve potential neuromuscular synapse neurotransmitter release nonhuman pathophysiology structure analysis synaptic transmission adult aging animal classification fetus genetics metabolism mouse neuromuscular junction disorder newborn physiology rat review secretion synaptic membrane Ataxia Adult Aging Animals Animals, Newborn Calcium Channels, L-Type Calcium Channels, N-Type Fetus Humans Mice Neuromuscular Junction Neuromuscular Junction Diseases Neurotransmitter Agents Potassium Rats Synaptic Membranes Synaptic Transmission Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunological target in Eaton-Lambert Syndrome. At adult neuromuscular junctions, L- and N-type Ca2+ channels become involved in transmitter release only under certain experimental or pathological conditions. In contrast, at neonatal rat neuromuscular junctions, nerve-evoked synaptic transmission depends jointly on both N- and P/Q-type channels. Synaptic transmission at neuromuscular junctions of the ataxic P/Q-type Ca2+ channel knockout mice is also dependent on two different types of channels, N- and R-type. At both neonatal and P/Q knockout junctions, the K +-evoked increase in miniature endplate potential frequency was not affected by N-type channel blockers, but strongly reduced by both P/Q- and R-type channel blockers. These differences could be accounted for by a differential location of the channels at the release site, being either P/Q- or R-type Ca2+ channels located closer to the release site than N-type Ca2+ channels. Thus, Ca2+ channels may be recruited to mediate neurotransmitter release where P/Q-type channels seem to be the most suited type of Ca2+ channel to mediate exocytosis at neuromuscular junctions. Fil:Nudler, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Piriz, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rosato-Siri, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00778923_v998_n_p11_Nudler
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium channels Calcium dependence Miniature endplate potentials Neuromuscular junction Transmitter release calcium channel calcium channel blocking agent calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type immunoglobulin neurotransmitter nitrendipine okadaic acid omega agatoxin omega agatoxin gvia omega agatoxin IVA snx 482 unclassified drug agents interacting with transmitter, hormone or drug receptors calcium channel N type potassium ataxia chemical structure conference paper drug effect dystonia Eaton Lambert syndrome electric potential electrophysiology endplate potential exocytosis experiment genetic analysis genetic code human immune system knockout mouse nerve ending nerve potential neuromuscular synapse neurotransmitter release nonhuman pathophysiology structure analysis synaptic transmission adult aging animal classification fetus genetics metabolism mouse neuromuscular junction disorder newborn physiology rat review secretion synaptic membrane Ataxia Adult Aging Animals Animals, Newborn Calcium Channels, L-Type Calcium Channels, N-Type Fetus Humans Mice Neuromuscular Junction Neuromuscular Junction Diseases Neurotransmitter Agents Potassium Rats Synaptic Membranes Synaptic Transmission
spellingShingle	Calcium channels Calcium dependence Miniature endplate potentials Neuromuscular junction Transmitter release calcium channel calcium channel blocking agent calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type immunoglobulin neurotransmitter nitrendipine okadaic acid omega agatoxin omega agatoxin gvia omega agatoxin IVA snx 482 unclassified drug agents interacting with transmitter, hormone or drug receptors calcium channel N type potassium ataxia chemical structure conference paper drug effect dystonia Eaton Lambert syndrome electric potential electrophysiology endplate potential exocytosis experiment genetic analysis genetic code human immune system knockout mouse nerve ending nerve potential neuromuscular synapse neurotransmitter release nonhuman pathophysiology structure analysis synaptic transmission adult aging animal classification fetus genetics metabolism mouse neuromuscular junction disorder newborn physiology rat review secretion synaptic membrane Ataxia Adult Aging Animals Animals, Newborn Calcium Channels, L-Type Calcium Channels, N-Type Fetus Humans Mice Neuromuscular Junction Neuromuscular Junction Diseases Neurotransmitter Agents Potassium Rats Synaptic Membranes Synaptic Transmission Nudler, S. Piriz, J. Urbano, F.J. Rosato-Siri, M.D. Piedras Renteria, E.S. Uchitel, O.D. Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
topic_facet	Calcium channels Calcium dependence Miniature endplate potentials Neuromuscular junction Transmitter release calcium channel calcium channel blocking agent calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type immunoglobulin neurotransmitter nitrendipine okadaic acid omega agatoxin omega agatoxin gvia omega agatoxin IVA snx 482 unclassified drug agents interacting with transmitter, hormone or drug receptors calcium channel N type potassium ataxia chemical structure conference paper drug effect dystonia Eaton Lambert syndrome electric potential electrophysiology endplate potential exocytosis experiment genetic analysis genetic code human immune system knockout mouse nerve ending nerve potential neuromuscular synapse neurotransmitter release nonhuman pathophysiology structure analysis synaptic transmission adult aging animal classification fetus genetics metabolism mouse neuromuscular junction disorder newborn physiology rat review secretion synaptic membrane Ataxia Adult Aging Animals Animals, Newborn Calcium Channels, L-Type Calcium Channels, N-Type Fetus Humans Mice Neuromuscular Junction Neuromuscular Junction Diseases Neurotransmitter Agents Potassium Rats Synaptic Membranes Synaptic Transmission
description	Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunological target in Eaton-Lambert Syndrome. At adult neuromuscular junctions, L- and N-type Ca2+ channels become involved in transmitter release only under certain experimental or pathological conditions. In contrast, at neonatal rat neuromuscular junctions, nerve-evoked synaptic transmission depends jointly on both N- and P/Q-type channels. Synaptic transmission at neuromuscular junctions of the ataxic P/Q-type Ca2+ channel knockout mice is also dependent on two different types of channels, N- and R-type. At both neonatal and P/Q knockout junctions, the K +-evoked increase in miniature endplate potential frequency was not affected by N-type channel blockers, but strongly reduced by both P/Q- and R-type channel blockers. These differences could be accounted for by a differential location of the channels at the release site, being either P/Q- or R-type Ca2+ channels located closer to the release site than N-type Ca2+ channels. Thus, Ca2+ channels may be recruited to mediate neurotransmitter release where P/Q-type channels seem to be the most suited type of Ca2+ channel to mediate exocytosis at neuromuscular junctions.
format	SER
author	Nudler, S. Piriz, J. Urbano, F.J. Rosato-Siri, M.D. Piedras Renteria, E.S. Uchitel, O.D.
author_facet	Nudler, S. Piriz, J. Urbano, F.J. Rosato-Siri, M.D. Piedras Renteria, E.S. Uchitel, O.D.
author_sort	Nudler, S.
title	Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
title_short	Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
title_full	Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
title_fullStr	Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
title_full_unstemmed	Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
title_sort	ca2+ channels and synaptic transmission at the adult, neonatal, and p/q-type deficient neuromuscular junction
url	http://hdl.handle.net/20.500.12110/paper_00778923_v998_n_p11_Nudler
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Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction

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